The effect of icodextrin-based solutions on peritoneal transport in rats undergoing chronic peritoneal dialysis

Krzysztof Pawlaczyk, Elvia Garcia-Lopez, Malgorzata Kuzlan-Pawlaczyk, Olof Heimbürger, Jonas Bergström, Andrzej Breborowicz, Bengt Lindholm

Research output: Contribution to journalArticle

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Abstract

◆ Background: We evaluated the effect of icodextrin on peritoneal permeability and inflammation in an experimental chronic peritoneal dialysis (PD) model with repeated dwell studies (DSs) in non uremic rats. ◆ Methods: Male Wistar rats with implanted peritoneal catheters were infused twice daily for 3 weeks with 20 mL Dianeal 3.86% (Baxter Healthcare Corporation, Deerfield, IL, U.S.A.) (n = 11) or icodextrin 7.5% (n = 12). After 10 days (DS1) and 21 days (DS2), a 4-hour DS using 30 mL icodextrin solution was performed in conscious animals. Radioiodinated serum albumin (RISA) was used as a macromolecular volume marker. Blood samples were drawn before the start of the dwell and at its end. ◆ Results: We observed a steady increase in intraperitoneal volume (IPV) versus dwell time (0 - 240 minutes) during DS1 and DS2 in both groups. No significant differences in peritoneal permeability to solutes were observed between the groups. However, in both groups, IPV volume was significantly higher during DS2 after the 4-hour dwell time [IPV icodextrin: 34.4 ± 1.4 mL (DS1), 35.4 ± 1.1 mL (DS2), p < 0.002; IPV Dianeal: 34.2 ± 0.9 mL (DS1), 35.2 ± 0.7 mL (DS2), p < 0.01]. ◆ Conclusion: Changes of peritoneal permeability seen during in vivo experimental models of chronic peritoneal dialysis in rats with repeated dwell studies are comparable to results obtained in humans on continuous ambulatory peritoneal dialysis (CAPD).

Original languageEnglish (US)
JournalPeritoneal Dialysis International
Volume21
Issue numberSUPPL. 3
StatePublished - 2001
Externally publishedYes

Fingerprint

Peritoneal Dialysis
Permeability
Radio-Iodinated Serum Albumin
Continuous Ambulatory Peritoneal Dialysis
Wistar Rats
Theoretical Models
Catheters
Inflammation
Delivery of Health Care
icodextrin

Keywords

  • Animal model
  • Icodextrin
  • Peritoneal transport
  • Repeated dwell studies
  • Ultrafiltration

ASJC Scopus subject areas

  • Nephrology

Cite this

Pawlaczyk, K., Garcia-Lopez, E., Kuzlan-Pawlaczyk, M., Heimbürger, O., Bergström, J., Breborowicz, A., & Lindholm, B. (2001). The effect of icodextrin-based solutions on peritoneal transport in rats undergoing chronic peritoneal dialysis. Peritoneal Dialysis International, 21(SUPPL. 3).

The effect of icodextrin-based solutions on peritoneal transport in rats undergoing chronic peritoneal dialysis. / Pawlaczyk, Krzysztof; Garcia-Lopez, Elvia; Kuzlan-Pawlaczyk, Malgorzata; Heimbürger, Olof; Bergström, Jonas; Breborowicz, Andrzej; Lindholm, Bengt.

In: Peritoneal Dialysis International, Vol. 21, No. SUPPL. 3, 2001.

Research output: Contribution to journalArticle

Pawlaczyk, K, Garcia-Lopez, E, Kuzlan-Pawlaczyk, M, Heimbürger, O, Bergström, J, Breborowicz, A & Lindholm, B 2001, 'The effect of icodextrin-based solutions on peritoneal transport in rats undergoing chronic peritoneal dialysis', Peritoneal Dialysis International, vol. 21, no. SUPPL. 3.
Pawlaczyk K, Garcia-Lopez E, Kuzlan-Pawlaczyk M, Heimbürger O, Bergström J, Breborowicz A et al. The effect of icodextrin-based solutions on peritoneal transport in rats undergoing chronic peritoneal dialysis. Peritoneal Dialysis International. 2001;21(SUPPL. 3).
Pawlaczyk, Krzysztof ; Garcia-Lopez, Elvia ; Kuzlan-Pawlaczyk, Malgorzata ; Heimbürger, Olof ; Bergström, Jonas ; Breborowicz, Andrzej ; Lindholm, Bengt. / The effect of icodextrin-based solutions on peritoneal transport in rats undergoing chronic peritoneal dialysis. In: Peritoneal Dialysis International. 2001 ; Vol. 21, No. SUPPL. 3.
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abstract = "◆ Background: We evaluated the effect of icodextrin on peritoneal permeability and inflammation in an experimental chronic peritoneal dialysis (PD) model with repeated dwell studies (DSs) in non uremic rats. ◆ Methods: Male Wistar rats with implanted peritoneal catheters were infused twice daily for 3 weeks with 20 mL Dianeal 3.86{\%} (Baxter Healthcare Corporation, Deerfield, IL, U.S.A.) (n = 11) or icodextrin 7.5{\%} (n = 12). After 10 days (DS1) and 21 days (DS2), a 4-hour DS using 30 mL icodextrin solution was performed in conscious animals. Radioiodinated serum albumin (RISA) was used as a macromolecular volume marker. Blood samples were drawn before the start of the dwell and at its end. ◆ Results: We observed a steady increase in intraperitoneal volume (IPV) versus dwell time (0 - 240 minutes) during DS1 and DS2 in both groups. No significant differences in peritoneal permeability to solutes were observed between the groups. However, in both groups, IPV volume was significantly higher during DS2 after the 4-hour dwell time [IPV icodextrin: 34.4 ± 1.4 mL (DS1), 35.4 ± 1.1 mL (DS2), p < 0.002; IPV Dianeal: 34.2 ± 0.9 mL (DS1), 35.2 ± 0.7 mL (DS2), p < 0.01]. ◆ Conclusion: Changes of peritoneal permeability seen during in vivo experimental models of chronic peritoneal dialysis in rats with repeated dwell studies are comparable to results obtained in humans on continuous ambulatory peritoneal dialysis (CAPD).",
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AU - Pawlaczyk, Krzysztof

AU - Garcia-Lopez, Elvia

AU - Kuzlan-Pawlaczyk, Malgorzata

AU - Heimbürger, Olof

AU - Bergström, Jonas

AU - Breborowicz, Andrzej

AU - Lindholm, Bengt

PY - 2001

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N2 - ◆ Background: We evaluated the effect of icodextrin on peritoneal permeability and inflammation in an experimental chronic peritoneal dialysis (PD) model with repeated dwell studies (DSs) in non uremic rats. ◆ Methods: Male Wistar rats with implanted peritoneal catheters were infused twice daily for 3 weeks with 20 mL Dianeal 3.86% (Baxter Healthcare Corporation, Deerfield, IL, U.S.A.) (n = 11) or icodextrin 7.5% (n = 12). After 10 days (DS1) and 21 days (DS2), a 4-hour DS using 30 mL icodextrin solution was performed in conscious animals. Radioiodinated serum albumin (RISA) was used as a macromolecular volume marker. Blood samples were drawn before the start of the dwell and at its end. ◆ Results: We observed a steady increase in intraperitoneal volume (IPV) versus dwell time (0 - 240 minutes) during DS1 and DS2 in both groups. No significant differences in peritoneal permeability to solutes were observed between the groups. However, in both groups, IPV volume was significantly higher during DS2 after the 4-hour dwell time [IPV icodextrin: 34.4 ± 1.4 mL (DS1), 35.4 ± 1.1 mL (DS2), p < 0.002; IPV Dianeal: 34.2 ± 0.9 mL (DS1), 35.2 ± 0.7 mL (DS2), p < 0.01]. ◆ Conclusion: Changes of peritoneal permeability seen during in vivo experimental models of chronic peritoneal dialysis in rats with repeated dwell studies are comparable to results obtained in humans on continuous ambulatory peritoneal dialysis (CAPD).

AB - ◆ Background: We evaluated the effect of icodextrin on peritoneal permeability and inflammation in an experimental chronic peritoneal dialysis (PD) model with repeated dwell studies (DSs) in non uremic rats. ◆ Methods: Male Wistar rats with implanted peritoneal catheters were infused twice daily for 3 weeks with 20 mL Dianeal 3.86% (Baxter Healthcare Corporation, Deerfield, IL, U.S.A.) (n = 11) or icodextrin 7.5% (n = 12). After 10 days (DS1) and 21 days (DS2), a 4-hour DS using 30 mL icodextrin solution was performed in conscious animals. Radioiodinated serum albumin (RISA) was used as a macromolecular volume marker. Blood samples were drawn before the start of the dwell and at its end. ◆ Results: We observed a steady increase in intraperitoneal volume (IPV) versus dwell time (0 - 240 minutes) during DS1 and DS2 in both groups. No significant differences in peritoneal permeability to solutes were observed between the groups. However, in both groups, IPV volume was significantly higher during DS2 after the 4-hour dwell time [IPV icodextrin: 34.4 ± 1.4 mL (DS1), 35.4 ± 1.1 mL (DS2), p < 0.002; IPV Dianeal: 34.2 ± 0.9 mL (DS1), 35.2 ± 0.7 mL (DS2), p < 0.01]. ◆ Conclusion: Changes of peritoneal permeability seen during in vivo experimental models of chronic peritoneal dialysis in rats with repeated dwell studies are comparable to results obtained in humans on continuous ambulatory peritoneal dialysis (CAPD).

KW - Animal model

KW - Icodextrin

KW - Peritoneal transport

KW - Repeated dwell studies

KW - Ultrafiltration

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