TY - JOUR
T1 - The effect of diazinon on blood glucose homeostasis
T2 - a systematic and meta-analysis study
AU - Farkhondeh, Tahereh
AU - Aschner, Michael
AU - Sadeghi, Mahmood
AU - Mehrpour, Omid
AU - Naseri, Kobra
AU - Amirabadizadeh, Alireza
AU - Roshanravan, Babak
AU - Aramjoo, Hamed
AU - Samarghandian, Saeed
N1 - Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/1
Y1 - 2021/1
N2 - Though evidence exists on the association between diazinon (DZN), an organophosphate pesticide, with hyperglycemia, contrasting reports also exist. Herein, we performed a systematic and meta-analysis study to address this issue. A systematic search was conducted in PubMed, Ovid Medline, Google Scholar, Scopus, and Web of Science up to April 5, 2020, searching for animal studies (rodents and fish) that assessed the impact of DZN on blood glucose concentration. The risk of bias was assessed by the SYRCLE’s RoB scale. Once each article’s quality was assessed, a random-effects meta-regression was used to pool the data into a meta-analysis. Heterogeneity between the studies was evaluated with the I square and Q test. Random-effect meta-analysis of 19 studies (I2 = 90.5%, p < 0.001) indicated low heterogeneity between the studies. DZN significantly increased blood glucose levels in the exposed versus control groups (95% CI: 2.46–4.94; Z = 5.86; p < 0.001). Subgroup analysis indicated that the effect of high-dose (3.40 (95% CI: 2.03–4.76)) DZN on changes in blood glucose was more pronounced than in the low dose (4.83 (95% CI: 1.56–8.11)). It was also ascertained that the blood glucose level was significantly higher in females (3.55 (95% CI: 2.21–4.89)) versus males (4.87 (95% CI: 0.20–9.55)) exposed to DZN. No publication bias was observed. Sensitivity analysis showed the robustness of the (standardized mean differences: 3.26–4.03). Our findings establish an association between DZN exposure and hyperglycemia in rodents and fish, which is both dose- and gender-dependent.
AB - Though evidence exists on the association between diazinon (DZN), an organophosphate pesticide, with hyperglycemia, contrasting reports also exist. Herein, we performed a systematic and meta-analysis study to address this issue. A systematic search was conducted in PubMed, Ovid Medline, Google Scholar, Scopus, and Web of Science up to April 5, 2020, searching for animal studies (rodents and fish) that assessed the impact of DZN on blood glucose concentration. The risk of bias was assessed by the SYRCLE’s RoB scale. Once each article’s quality was assessed, a random-effects meta-regression was used to pool the data into a meta-analysis. Heterogeneity between the studies was evaluated with the I square and Q test. Random-effect meta-analysis of 19 studies (I2 = 90.5%, p < 0.001) indicated low heterogeneity between the studies. DZN significantly increased blood glucose levels in the exposed versus control groups (95% CI: 2.46–4.94; Z = 5.86; p < 0.001). Subgroup analysis indicated that the effect of high-dose (3.40 (95% CI: 2.03–4.76)) DZN on changes in blood glucose was more pronounced than in the low dose (4.83 (95% CI: 1.56–8.11)). It was also ascertained that the blood glucose level was significantly higher in females (3.55 (95% CI: 2.21–4.89)) versus males (4.87 (95% CI: 0.20–9.55)) exposed to DZN. No publication bias was observed. Sensitivity analysis showed the robustness of the (standardized mean differences: 3.26–4.03). Our findings establish an association between DZN exposure and hyperglycemia in rodents and fish, which is both dose- and gender-dependent.
KW - Blood glucose levels
KW - Diazinon
KW - Fish
KW - Organophosphate pesticides
KW - Rodent
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U2 - 10.1007/s11356-020-11364-0
DO - 10.1007/s11356-020-11364-0
M3 - Review article
C2 - 33175357
AN - SCOPUS:85096018553
SN - 0944-1344
VL - 28
SP - 4007
EP - 4018
JO - Environmental Science and Pollution Research
JF - Environmental Science and Pollution Research
IS - 4
ER -