The effect of chemoreceptor stimulation upon muscle sympathetic nerve activity

Gregory J. Gates, Matthew N. Bartels, John A. Downey, Ronald E. De Meersman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this investigation was to quantify the combined peripheral and central chemoreceptor contribution to sympathetic outflow above (post) and below (pre) the chemoreceptor ventilatory threshold (CVT). We measured muscle sympathetic nerve activity (MSNA) in seven subjects during hypoxic/hypercapnic and room air rebreathe protocols. Comparisons were made using a repeated measures analysis of variance with two within subject factors. One factor contained three levels-hyperventilation, pre-CVT, and post-CVT. The other factor contained two levels-rebreathe and control. Total MSNA increased from hyperventilation to pre-CVT to post-CVT in the rebreathe trial (385.7 ± 95.9, 592.4 ± 155.7, 882.0 ± 235.4 au/15 s respectively) and remained constant in the control trial (433.0 ± 189.3, 409.1 ± 183.4, 406.1 ± 161.4 au/15 s respectively). Ventilation increased in the rebreathe trial only. Heart rate and blood pressure did not change in either trial. These data suggest that the chemoreceptors significantly contribute to the modulation of sympathetic outflow.

Original languageEnglish (US)
Pages (from-to)268-272
Number of pages5
JournalRespiratory Physiology and Neurobiology
Volume167
Issue number3
DOIs
StatePublished - Jul 31 2009
Externally publishedYes

Fingerprint

Hyperventilation
Muscles
Ventilation
Analysis of Variance
Heart Rate
Air
Blood Pressure

Keywords

  • Autonomic
  • Chemoreceptor
  • Sympathetic
  • Ventilation

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

The effect of chemoreceptor stimulation upon muscle sympathetic nerve activity. / Gates, Gregory J.; Bartels, Matthew N.; Downey, John A.; De Meersman, Ronald E.

In: Respiratory Physiology and Neurobiology, Vol. 167, No. 3, 31.07.2009, p. 268-272.

Research output: Contribution to journalArticle

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