The Drosophila DmGluRA is required for social interaction and memory

Brian P. Schoenfeld, Richard J. Choi, Catherine H. Choi, Allison M. Terlizzi, Paul Hinchey, Maria Kollaros, Neal J. Ferrick, Eric Koenigsberg, David Ferreiro, David A. Leibelt, Steven J. Siegel, Aaron J. Bell, Thomas V. McDonald, Thomas A. Jongens, Sean M J McBride

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Metabotropic glutamate receptors (mGluRs) have well-established roles in cognition and social behavior in mammals. Whether or not these roles have been conserved throughout evolution from invertebrate species is less clear. Mammals have eight mGluRs whereas Drosophila has a single DmGluRA, which has both Gi and Gq coupled signaling activity. We have utilized Drosophila to examine the role of DmGluRA in social behavior and various phases of memory. We have found that flies that are homozygous or heterozygous for loss of function mutations of DmGluRA have impaired social behavior in male Drosophila. Futhermore, flies that are heterozygous for loss of function mutations of DmGluRA have impaired learning during training, immediate-recall memory, short-term memory, and long-term memory as young adults. This work demonstrates a role for mGluR activity in both social behavior and memory in Drosophila.

Original languageEnglish (US)
Article number64
JournalFrontiers in Pharmacology
Volume4 MAY
DOIs
StatePublished - 2013

Fingerprint

Social Behavior
Interpersonal Relations
Drosophila
Short-Term Memory
Metabotropic Glutamate Receptors
Diptera
Mammals
Mutation
Long-Term Memory
Invertebrates
Cognition
Young Adult
Learning

Keywords

  • DmGluRA
  • Drosophila
  • Learning
  • Long-term memory
  • Memory
  • mGluR

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Schoenfeld, B. P., Choi, R. J., Choi, C. H., Terlizzi, A. M., Hinchey, P., Kollaros, M., ... McBride, S. M. J. (2013). The Drosophila DmGluRA is required for social interaction and memory. Frontiers in Pharmacology, 4 MAY, [64]. https://doi.org/10.3389/fphar.2013.00064

The Drosophila DmGluRA is required for social interaction and memory. / Schoenfeld, Brian P.; Choi, Richard J.; Choi, Catherine H.; Terlizzi, Allison M.; Hinchey, Paul; Kollaros, Maria; Ferrick, Neal J.; Koenigsberg, Eric; Ferreiro, David; Leibelt, David A.; Siegel, Steven J.; Bell, Aaron J.; McDonald, Thomas V.; Jongens, Thomas A.; McBride, Sean M J.

In: Frontiers in Pharmacology, Vol. 4 MAY, 64, 2013.

Research output: Contribution to journalArticle

Schoenfeld, BP, Choi, RJ, Choi, CH, Terlizzi, AM, Hinchey, P, Kollaros, M, Ferrick, NJ, Koenigsberg, E, Ferreiro, D, Leibelt, DA, Siegel, SJ, Bell, AJ, McDonald, TV, Jongens, TA & McBride, SMJ 2013, 'The Drosophila DmGluRA is required for social interaction and memory', Frontiers in Pharmacology, vol. 4 MAY, 64. https://doi.org/10.3389/fphar.2013.00064
Schoenfeld BP, Choi RJ, Choi CH, Terlizzi AM, Hinchey P, Kollaros M et al. The Drosophila DmGluRA is required for social interaction and memory. Frontiers in Pharmacology. 2013;4 MAY. 64. https://doi.org/10.3389/fphar.2013.00064
Schoenfeld, Brian P. ; Choi, Richard J. ; Choi, Catherine H. ; Terlizzi, Allison M. ; Hinchey, Paul ; Kollaros, Maria ; Ferrick, Neal J. ; Koenigsberg, Eric ; Ferreiro, David ; Leibelt, David A. ; Siegel, Steven J. ; Bell, Aaron J. ; McDonald, Thomas V. ; Jongens, Thomas A. ; McBride, Sean M J. / The Drosophila DmGluRA is required for social interaction and memory. In: Frontiers in Pharmacology. 2013 ; Vol. 4 MAY.
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