The Drosophila clock gene per affects intercellular junctional communication

Thaddeus A. Bargiello; Lino Saez; Mary K. Baylies; Gregory Gasic; Michael W. Young; David C. Spray

doi:10.1038/328686a0

The Drosophila clock gene per affects intercellular junctional communication

Thaddeus A. Bargiello, Lino Saez, Mary K. Baylies, Gregory Gasic, Michael W. Young, David C. Spray

Neuroscience

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65 Scopus citations

Abstract

The per locus of Drosophila has been implicated in the control of behavioural rhythms. In fruitfly embryos and larvae per is expressed in salivary glands. Per mutations have striking effects on intercellular communication in salivary glands: gap junction channels are modulated so that their conductance varies inversely with the period of behavioural rhythms in the mutants. A similar effect on junctional communication in the nervous system may explain how per influences behavioural rhythms.

Original language	English (US)
Pages (from-to)	686-691
Number of pages	6
Journal	Nature
Volume	328
Issue number	6132
DOIs	https://doi.org/10.1038/328686a0
State	Published - 1988

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title = "The Drosophila clock gene per affects intercellular junctional communication",

abstract = "The per locus of Drosophila has been implicated in the control of behavioural rhythms. In fruitfly embryos and larvae per is expressed in salivary glands. Per mutations have striking effects on intercellular communication in salivary glands: gap junction channels are modulated so that their conductance varies inversely with the period of behavioural rhythms in the mutants. A similar effect on junctional communication in the nervous system may explain how per influences behavioural rhythms.",

author = "Bargiello, {Thaddeus A.} and Lino Saez and Baylies, {Mary K.} and Gregory Gasic and Young, {Michael W.} and Spray, {David C.}",

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AU - Bargiello, Thaddeus A.

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AU - Gasic, Gregory

AU - Young, Michael W.

AU - Spray, David C.

PY - 1988

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N2 - The per locus of Drosophila has been implicated in the control of behavioural rhythms. In fruitfly embryos and larvae per is expressed in salivary glands. Per mutations have striking effects on intercellular communication in salivary glands: gap junction channels are modulated so that their conductance varies inversely with the period of behavioural rhythms in the mutants. A similar effect on junctional communication in the nervous system may explain how per influences behavioural rhythms.

AB - The per locus of Drosophila has been implicated in the control of behavioural rhythms. In fruitfly embryos and larvae per is expressed in salivary glands. Per mutations have striking effects on intercellular communication in salivary glands: gap junction channels are modulated so that their conductance varies inversely with the period of behavioural rhythms in the mutants. A similar effect on junctional communication in the nervous system may explain how per influences behavioural rhythms.

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The Drosophila clock gene per affects intercellular junctional communication

Abstract

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