The Different Routes to Metastasis via Hypoxia-Regulated Programs

Ana Rita Nobre, David R. Entenberg, Yarong Wang, John S. Condeelis, Julio A. Aguirre-Ghiso

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we review the pros and cons of in vitro hypoxia assays, highlight in vivo studies that inform on physiological hypoxia, and review the evidence that primary tumor hypoxia might influence the fate of disseminated tumor cells (DTCs) in secondary organs. Our analysis suggests that consensus can be reached by using in vivo methods of study, which also allow better modeling of how hypoxia affects DTC fate and metastasis.

Original languageEnglish (US)
JournalTrends in Cell Biology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Neoplasm Metastasis
Neoplasms
Hypoxia
In Vitro Techniques

Keywords

  • disseminated tumor cell
  • dormancy
  • hypoxia
  • hypoxia probes
  • hypoxia sensor

ASJC Scopus subject areas

  • Cell Biology

Cite this

The Different Routes to Metastasis via Hypoxia-Regulated Programs. / Nobre, Ana Rita; Entenberg, David R.; Wang, Yarong; Condeelis, John S.; Aguirre-Ghiso, Julio A.

In: Trends in Cell Biology, 01.01.2018.

Research output: Contribution to journalArticle

@article{c47f29db9d41441383b02b8d79be10fd,
title = "The Different Routes to Metastasis via Hypoxia-Regulated Programs",
abstract = "Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we review the pros and cons of in vitro hypoxia assays, highlight in vivo studies that inform on physiological hypoxia, and review the evidence that primary tumor hypoxia might influence the fate of disseminated tumor cells (DTCs) in secondary organs. Our analysis suggests that consensus can be reached by using in vivo methods of study, which also allow better modeling of how hypoxia affects DTC fate and metastasis.",
keywords = "disseminated tumor cell, dormancy, hypoxia, hypoxia probes, hypoxia sensor",
author = "Nobre, {Ana Rita} and Entenberg, {David R.} and Yarong Wang and Condeelis, {John S.} and Aguirre-Ghiso, {Julio A.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.tcb.2018.06.008",
language = "English (US)",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - The Different Routes to Metastasis via Hypoxia-Regulated Programs

AU - Nobre, Ana Rita

AU - Entenberg, David R.

AU - Wang, Yarong

AU - Condeelis, John S.

AU - Aguirre-Ghiso, Julio A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we review the pros and cons of in vitro hypoxia assays, highlight in vivo studies that inform on physiological hypoxia, and review the evidence that primary tumor hypoxia might influence the fate of disseminated tumor cells (DTCs) in secondary organs. Our analysis suggests that consensus can be reached by using in vivo methods of study, which also allow better modeling of how hypoxia affects DTC fate and metastasis.

AB - Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we review the pros and cons of in vitro hypoxia assays, highlight in vivo studies that inform on physiological hypoxia, and review the evidence that primary tumor hypoxia might influence the fate of disseminated tumor cells (DTCs) in secondary organs. Our analysis suggests that consensus can be reached by using in vivo methods of study, which also allow better modeling of how hypoxia affects DTC fate and metastasis.

KW - disseminated tumor cell

KW - dormancy

KW - hypoxia

KW - hypoxia probes

KW - hypoxia sensor

UR - http://www.scopus.com/inward/record.url?scp=85050114624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050114624&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2018.06.008

DO - 10.1016/j.tcb.2018.06.008

M3 - Article

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

ER -