The cytoplasmic fate of an mRNP is determined cotranscriptionally

Exception or rule?

Tatjana Trcek, Robert H. Singer

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

Original languageEnglish (US)
Pages (from-to)1827-1831
Number of pages5
JournalGenes and Development
Volume24
Issue number17
DOIs
StatePublished - Sep 1 2010

Fingerprint

Messenger RNA
RNA-Binding Proteins
Yeasts
Genes
Proteins
messenger ribonucleoprotein

Keywords

  • Cotranscriptional
  • Localization
  • mRNA
  • She2p
  • Spt4p
  • Spt5p
  • Yeast

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

The cytoplasmic fate of an mRNP is determined cotranscriptionally : Exception or rule? / Trcek, Tatjana; Singer, Robert H.

In: Genes and Development, Vol. 24, No. 17, 01.09.2010, p. 1827-1831.

Research output: Contribution to journalArticle

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