The cytoplasmic fate of an mRNP is determined cotranscriptionally: Exception or rule?

Tatjana Trcek, Robert H. Singer

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

Original languageEnglish (US)
Pages (from-to)1827-1831
Number of pages5
JournalGenes and Development
Volume24
Issue number17
DOIs
StatePublished - Sep 1 2010

Keywords

  • Cotranscriptional
  • Localization
  • She2p
  • Spt4p
  • Spt5p
  • Yeast
  • mRNA

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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