The connectome of a decision-making neural network

Travis A. Jarrell, Yi Wang, Adam E. Bloniarz, Christopher A. Brittin, Meng Xu, J. Nichol Thomson, Donna G. Albertson, David H. Hall, Scott W. Emmons

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

In order to understand the nervous system, it is necessary to know the synaptic connections between the neurons, yet to date, only the wiring diagram of the adult hermaphrodite of the nematode Caenorhabditis elegans has been determined. Here, we present the wiring diagram of the posterior nervous system of the C. elegans adult male, reconstructed from serial electron micrograph sections. This region of the male nervous system contains the sexually dimorphic circuits for mating. The synaptic connections, both chemical and gap junctional, form a neural network with four striking features: multiple, parallel, short synaptic pathways directly connecting sensory neurons to end organs; recurrent and reciprocal connectivity among sensory neurons; modular substructure; and interneurons acting in feedforward loops. These features help to explain how the network robustly and rapidly selects and executes the steps of a behavioral program on the basis of the inputs from multiple sensory neurons.

Original languageEnglish (US)
Pages (from-to)437-444
Number of pages8
JournalScience
Volume337
Issue number6093
DOIs
StatePublished - Jul 27 2012

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Connectome
Sensory Receptor Cells
Nervous System
Decision Making
Caenorhabditis elegans
Interneurons
Electrons
Neurons

ASJC Scopus subject areas

  • General

Cite this

Jarrell, T. A., Wang, Y., Bloniarz, A. E., Brittin, C. A., Xu, M., Thomson, J. N., ... Emmons, S. W. (2012). The connectome of a decision-making neural network. Science, 337(6093), 437-444. https://doi.org/10.1126/science.1221762

The connectome of a decision-making neural network. / Jarrell, Travis A.; Wang, Yi; Bloniarz, Adam E.; Brittin, Christopher A.; Xu, Meng; Thomson, J. Nichol; Albertson, Donna G.; Hall, David H.; Emmons, Scott W.

In: Science, Vol. 337, No. 6093, 27.07.2012, p. 437-444.

Research output: Contribution to journalArticle

Jarrell, TA, Wang, Y, Bloniarz, AE, Brittin, CA, Xu, M, Thomson, JN, Albertson, DG, Hall, DH & Emmons, SW 2012, 'The connectome of a decision-making neural network', Science, vol. 337, no. 6093, pp. 437-444. https://doi.org/10.1126/science.1221762
Jarrell TA, Wang Y, Bloniarz AE, Brittin CA, Xu M, Thomson JN et al. The connectome of a decision-making neural network. Science. 2012 Jul 27;337(6093):437-444. https://doi.org/10.1126/science.1221762
Jarrell, Travis A. ; Wang, Yi ; Bloniarz, Adam E. ; Brittin, Christopher A. ; Xu, Meng ; Thomson, J. Nichol ; Albertson, Donna G. ; Hall, David H. ; Emmons, Scott W. / The connectome of a decision-making neural network. In: Science. 2012 ; Vol. 337, No. 6093. pp. 437-444.
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