The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling

Jun Liang, Robyn Lints, Marisa L. Foehr, Rafal Tokarz, Ling Yu, Scott W. Emmons, Ju Liu, Cathy Savage-Dunn

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

In Caenorhabditis elegans, the DBL-1 pathway, a BMP/TGFβ-related signaling cascade, regulates body size and male tail development. We have cloned a new gene, sma-9, that encodes the C. elegans homolog of Schnurri, a large zinc finger transcription factor that regulates dpp target genes in Drosophila. Genetic interactions, the sma-9 loss-of-function phenotype, and the expression pattern suggest that sma-9 acts as a downstream component and is required in the DBL-1 signaling pathway, and thus provide the first evidence of a conserved role for Schnurri proteins in BMP signaling. Analysis of sma-9 mutant phenotypes demonstrates that SMA-9 activity is temporally and spatially restricted relative to known DBL-1 pathway components. In contrast with Drosophila schnurri, the presence of multiple alternatively spliced sma-9 transcripts suggests protein isoforms with potentially different cell sublocalization and molecular functions. We propose that SMA-9 isoforms function as transcriptional cofactors that confer specific responses to DBL-1 pathway activation.

Original languageEnglish (US)
Pages (from-to)6453-6464
Number of pages12
JournalDevelopment
Volume130
Issue number26
DOIs
StatePublished - Dec 2003

Fingerprint

Caenorhabditis elegans
Drosophila
Protein Isoforms
Phenotype
Zinc Fingers
Body Size
Genes
Tail
Transcription Factors
Proteins

Keywords

  • Alternative splicing
  • BMP
  • Body size
  • Pattern formation
  • Schnurri
  • Transcription factor

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling. / Liang, Jun; Lints, Robyn; Foehr, Marisa L.; Tokarz, Rafal; Yu, Ling; Emmons, Scott W.; Liu, Ju; Savage-Dunn, Cathy.

In: Development, Vol. 130, No. 26, 12.2003, p. 6453-6464.

Research output: Contribution to journalArticle

Liang, Jun ; Lints, Robyn ; Foehr, Marisa L. ; Tokarz, Rafal ; Yu, Ling ; Emmons, Scott W. ; Liu, Ju ; Savage-Dunn, Cathy. / The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling. In: Development. 2003 ; Vol. 130, No. 26. pp. 6453-6464.
@article{5c9bc85f2dc34d5dac0516a79446adb0,
title = "The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling",
abstract = "In Caenorhabditis elegans, the DBL-1 pathway, a BMP/TGFβ-related signaling cascade, regulates body size and male tail development. We have cloned a new gene, sma-9, that encodes the C. elegans homolog of Schnurri, a large zinc finger transcription factor that regulates dpp target genes in Drosophila. Genetic interactions, the sma-9 loss-of-function phenotype, and the expression pattern suggest that sma-9 acts as a downstream component and is required in the DBL-1 signaling pathway, and thus provide the first evidence of a conserved role for Schnurri proteins in BMP signaling. Analysis of sma-9 mutant phenotypes demonstrates that SMA-9 activity is temporally and spatially restricted relative to known DBL-1 pathway components. In contrast with Drosophila schnurri, the presence of multiple alternatively spliced sma-9 transcripts suggests protein isoforms with potentially different cell sublocalization and molecular functions. We propose that SMA-9 isoforms function as transcriptional cofactors that confer specific responses to DBL-1 pathway activation.",
keywords = "Alternative splicing, BMP, Body size, Pattern formation, Schnurri, Transcription factor",
author = "Jun Liang and Robyn Lints and Foehr, {Marisa L.} and Rafal Tokarz and Ling Yu and Emmons, {Scott W.} and Ju Liu and Cathy Savage-Dunn",
year = "2003",
month = "12",
doi = "10.1242/dev.00863",
language = "English (US)",
volume = "130",
pages = "6453--6464",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "26",

}

TY - JOUR

T1 - The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling

AU - Liang, Jun

AU - Lints, Robyn

AU - Foehr, Marisa L.

AU - Tokarz, Rafal

AU - Yu, Ling

AU - Emmons, Scott W.

AU - Liu, Ju

AU - Savage-Dunn, Cathy

PY - 2003/12

Y1 - 2003/12

N2 - In Caenorhabditis elegans, the DBL-1 pathway, a BMP/TGFβ-related signaling cascade, regulates body size and male tail development. We have cloned a new gene, sma-9, that encodes the C. elegans homolog of Schnurri, a large zinc finger transcription factor that regulates dpp target genes in Drosophila. Genetic interactions, the sma-9 loss-of-function phenotype, and the expression pattern suggest that sma-9 acts as a downstream component and is required in the DBL-1 signaling pathway, and thus provide the first evidence of a conserved role for Schnurri proteins in BMP signaling. Analysis of sma-9 mutant phenotypes demonstrates that SMA-9 activity is temporally and spatially restricted relative to known DBL-1 pathway components. In contrast with Drosophila schnurri, the presence of multiple alternatively spliced sma-9 transcripts suggests protein isoforms with potentially different cell sublocalization and molecular functions. We propose that SMA-9 isoforms function as transcriptional cofactors that confer specific responses to DBL-1 pathway activation.

AB - In Caenorhabditis elegans, the DBL-1 pathway, a BMP/TGFβ-related signaling cascade, regulates body size and male tail development. We have cloned a new gene, sma-9, that encodes the C. elegans homolog of Schnurri, a large zinc finger transcription factor that regulates dpp target genes in Drosophila. Genetic interactions, the sma-9 loss-of-function phenotype, and the expression pattern suggest that sma-9 acts as a downstream component and is required in the DBL-1 signaling pathway, and thus provide the first evidence of a conserved role for Schnurri proteins in BMP signaling. Analysis of sma-9 mutant phenotypes demonstrates that SMA-9 activity is temporally and spatially restricted relative to known DBL-1 pathway components. In contrast with Drosophila schnurri, the presence of multiple alternatively spliced sma-9 transcripts suggests protein isoforms with potentially different cell sublocalization and molecular functions. We propose that SMA-9 isoforms function as transcriptional cofactors that confer specific responses to DBL-1 pathway activation.

KW - Alternative splicing

KW - BMP

KW - Body size

KW - Pattern formation

KW - Schnurri

KW - Transcription factor

UR - http://www.scopus.com/inward/record.url?scp=0347135664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347135664&partnerID=8YFLogxK

U2 - 10.1242/dev.00863

DO - 10.1242/dev.00863

M3 - Article

C2 - 14627718

AN - SCOPUS:0347135664

VL - 130

SP - 6453

EP - 6464

JO - Development (Cambridge)

JF - Development (Cambridge)

SN - 0950-1991

IS - 26

ER -