@article{ce7c3fda11b84949bc6ef87a97f2a720,
title = "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1",
abstract = "The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen. Similarly, the receptor for the murine colony-stimulating factor, CSF-1, is restricted to cells of the mononuclear phagocytic lineage and is a 165 kd glycoprotein with an associated tyrosine kinase. Rabbit antisera to a recombinant v-fms-coded polypeptide precipitated the feline c-fms product and specifically cross-reacted with a 165 kd glycoprotein from mouse macrophages. This putative product of the murine c-fms gene exhibited an associated tyrosine kinase activity in immune complexes, specifically bound murine CSF-1, and, in the presence of the growth factor, was phosphorylated on tyrosine in membrane preparations. The murine c-fms proto-oncogene product and the CSF-1 receptor are therefore related, and possibly identical, molecules.",
author = "Sherr, {Charles J.} and Rettenmier, {Carl W.} and Rosalba Sacca and Roussel, {Martine F.} and Look, {A. Thomas} and Stanley, {E. Richard}",
note = "Funding Information: We thank Drs. William S. Walker, Wayne L. Furman, Richard A. Ash-mun, Carl W. Jackson, J. H. Chen, Stephen C. Peiper, and Mary H. Walker for advice and assistance with some of the experiments. Shawn Hawkins Kramer, Jean McLarty Elmendorf, Virgil R Holder, Claudia Saez, and Michael Straign provided excellent technical support. We are grateful to Drs. Arthur W. Nienhuis, Thomas E Deuel, and Joseph V. Simone for helpful discussions and encouragement, to Peggy L. Bur-dick for secretarial assistance, and to the Department of Photography, St. Jude Children's Research Hospital. We also acknowledge the generous gifts of purified growth factors from Drs. David W. Golde, Allan L. Goldstein, Ajit Kumar, Keith Humphries, Allen C. Eaves, James N. Ihle, Peter T. Lomedico, Anna M. Skalka, and Patrick W. Trown, and rabbit antiserum to the EGF receptor kindly provided by Dr. Graham Carpenter. This work was supported by grants CA 38187 (C. J. S.) and CA 26504 (E. R. S.) from the National Cancer Institute; by Cancer Center (Core) grant CA-21765 (St. Jude); by an AECOM Cancer Center (Core) grant (Albert Einstein College of Medicine, E. R. S.); and by the American Lebanese Syrian Associated Charities of St. Jude Children's Research Hospital. E. R. S. is a recipient of an Irma T. Hirschl Career Scientist Award, C. W. R. was supported by a Biomedical Research Support grant (RR-05584-20) from the National Institutes of Health, and R. S. was supported by NIH training grant CA 09173. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked {"}advertisement{"} in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.",
year = "1985",
month = jul,
doi = "10.1016/S0092-8674(85)80047-7",
language = "English (US)",
volume = "41",
pages = "665--676",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",
}