The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

Charles J. Sherr, Carl W. Rettenmier, Rosalba Sacca, Martine F. Roussel, A. Thomas Look, E. Richard Stanley

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Abstract

The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen. Similarly, the receptor for the murine colony-stimulating factor, CSF-1, is restricted to cells of the mononuclear phagocytic lineage and is a 165 kd glycoprotein with an associated tyrosine kinase. Rabbit antisera to a recombinant v-fms-coded polypeptide precipitated the feline c-fms product and specifically cross-reacted with a 165 kd glycoprotein from mouse macrophages. This putative product of the murine c-fms gene exhibited an associated tyrosine kinase activity in immune complexes, specifically bound murine CSF-1, and, in the presence of the growth factor, was phosphorylated on tyrosine in membrane preparations. The murine c-fms proto-oncogene product and the CSF-1 receptor are therefore related, and possibly identical, molecules.

Original languageEnglish (US)
Pages (from-to)665-676
Number of pages12
JournalCell
Volume41
Issue number3
DOIs
StatePublished - Jul 1985

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Sherr, C. J., Rettenmier, C. W., Sacca, R., Roussel, M. F., Look, A. T., & Stanley, E. R. (1985). The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1. Cell, 41(3), 665-676. https://doi.org/10.1016/S0092-8674(85)80047-7