The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

Charles J. Sherr, Carl W. Rettenmier, Rosalba Sacca, Martine F. Roussel, A. Thomas Look, E. Richard Stanley

Research output: Contribution to journalArticle

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Abstract

The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen. Similarly, the receptor for the murine colony-stimulating factor, CSF-1, is restricted to cells of the mononuclear phagocytic lineage and is a 165 kd glycoprotein with an associated tyrosine kinase. Rabbit antisera to a recombinant v-fms-coded polypeptide precipitated the feline c-fms product and specifically cross-reacted with a 165 kd glycoprotein from mouse macrophages. This putative product of the murine c-fms gene exhibited an associated tyrosine kinase activity in immune complexes, specifically bound murine CSF-1, and, in the presence of the growth factor, was phosphorylated on tyrosine in membrane preparations. The murine c-fms proto-oncogene product and the CSF-1 receptor are therefore related, and possibly identical, molecules.

Original languageEnglish (US)
Pages (from-to)665-676
Number of pages12
JournalCell
Volume41
Issue number3
DOIs
StatePublished - 1985

Fingerprint

fms Genes
Macrophage Colony-Stimulating Factor
Oncogene Proteins
Phagocytes
Intercellular Signaling Peptides and Proteins
Glycoproteins
Protein-Tyrosine Kinases
Macrophages
Felidae
Macrophage Colony-Stimulating Factor Receptors
Colony-Stimulating Factors
Peritoneal Macrophages
Exudates and Transudates
Antigen-Antibody Complex
Tyrosine
Immune Sera
Cats
Spleen
Genes
Rabbits

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Sherr, C. J., Rettenmier, C. W., Sacca, R., Roussel, M. F., Look, A. T., & Stanley, E. R. (1985). The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1. Cell, 41(3), 665-676. https://doi.org/10.1016/S0092-8674(85)80047-7

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1. / Sherr, Charles J.; Rettenmier, Carl W.; Sacca, Rosalba; Roussel, Martine F.; Look, A. Thomas; Stanley, E. Richard.

In: Cell, Vol. 41, No. 3, 1985, p. 665-676.

Research output: Contribution to journalArticle

Sherr, CJ, Rettenmier, CW, Sacca, R, Roussel, MF, Look, AT & Stanley, ER 1985, 'The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1', Cell, vol. 41, no. 3, pp. 665-676. https://doi.org/10.1016/S0092-8674(85)80047-7
Sherr, Charles J. ; Rettenmier, Carl W. ; Sacca, Rosalba ; Roussel, Martine F. ; Look, A. Thomas ; Stanley, E. Richard. / The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1. In: Cell. 1985 ; Vol. 41, No. 3. pp. 665-676.
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