The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster

Linda A. Cannizzaro, Peter C. Nowell, Jean B. Belasco, Carlo M. Croce, Beverly S. Emanuel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

With a constant region probe (c-lambda) from the immunoglobulin light chain gene cluster, we performed in situ hybridization to bone marrow chromosome preparations from a patient with a Ph-positive form of acute lymphocytic leukemia. Results in this patient indicate that the immunoglobulin chain genes were involved in the 9;22 chromosome rearrangement.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume18
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

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Immunoglobulin Light Chain Genes
Multigene Family
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunoglobulin lambda-Chains
Immunoglobulin Subunits
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Immunoglobulin Genes
In Situ Hybridization
Chromosomes
Bone Marrow

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster. / Cannizzaro, Linda A.; Nowell, Peter C.; Belasco, Jean B.; Croce, Carlo M.; Emanuel, Beverly S.

In: Cancer Genetics and Cytogenetics, Vol. 18, No. 2, 1985, p. 173-177.

Research output: Contribution to journalArticle

Cannizzaro, Linda A. ; Nowell, Peter C. ; Belasco, Jean B. ; Croce, Carlo M. ; Emanuel, Beverly S. / The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster. In: Cancer Genetics and Cytogenetics. 1985 ; Vol. 18, No. 2. pp. 173-177.
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