The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster

Linda A. Cannizzaro, Peter C. Nowell, Jean B. Belasco, Carlo M. Croce, Beverly S. Emanuel

Research output: Contribution to journalArticle

6 Scopus citations


With a constant region probe (c-lambda) from the immunoglobulin light chain gene cluster, we performed in situ hybridization to bone marrow chromosome preparations from a patient with a Ph-positive form of acute lymphocytic leukemia. Results in this patient indicate that the immunoglobulin chain genes were involved in the 9;22 chromosome rearrangement.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalCancer Genetics and Cytogenetics
Issue number2
Publication statusPublished - Oct 1985


ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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