The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster

Linda A. Cannizzaro; Peter C. Nowell; Jean B. Belasco; Carlo M. Croce; Beverly S. Emanuel

doi:10.1016/0165-4608(85)90067-6

The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster

Linda A. Cannizzaro, Peter C. Nowell, Jean B. Belasco, Carlo M. Croce, Beverly S. Emanuel

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

With a constant region probe (c-lambda) from the immunoglobulin light chain gene cluster, we performed in situ hybridization to bone marrow chromosome preparations from a patient with a Ph-positive form of acute lymphocytic leukemia. Results in this patient indicate that the immunoglobulin chain genes were involved in the 9;22 chromosome rearrangement.

Original language	English (US)
Pages (from-to)	173-177
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(85)90067-6
State	Published - Oct 1985
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-4608(85)90067-6

Cite this

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title = "The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster",

abstract = "With a constant region probe (c-lambda) from the immunoglobulin light chain gene cluster, we performed in situ hybridization to bone marrow chromosome preparations from a patient with a Ph-positive form of acute lymphocytic leukemia. Results in this patient indicate that the immunoglobulin chain genes were involved in the 9;22 chromosome rearrangement.",

author = "Cannizzaro, {Linda A.} and Nowell, {Peter C.} and Belasco, {Jean B.} and Croce, {Carlo M.} and Emanuel, {Beverly S.}",

year = "1985",

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AU - Cannizzaro, Linda A.

AU - Nowell, Peter C.

AU - Belasco, Jean B.

AU - Croce, Carlo M.

AU - Emanuel, Beverly S.

PY - 1985/10

Y1 - 1985/10

N2 - With a constant region probe (c-lambda) from the immunoglobulin light chain gene cluster, we performed in situ hybridization to bone marrow chromosome preparations from a patient with a Ph-positive form of acute lymphocytic leukemia. Results in this patient indicate that the immunoglobulin chain genes were involved in the 9;22 chromosome rearrangement.

AB - With a constant region probe (c-lambda) from the immunoglobulin light chain gene cluster, we performed in situ hybridization to bone marrow chromosome preparations from a patient with a Ph-positive form of acute lymphocytic leukemia. Results in this patient indicate that the immunoglobulin chain genes were involved in the 9;22 chromosome rearrangement.

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The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster

Abstract

ASJC Scopus subject areas

UN SDGs

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