The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface

Ariel D. Stock, Sivan Gelb, Ofer Pasternak, Ayal Ben-Zvi, Chaim Putterman

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Experts have previously postulated a linkage between lupus associated vascular pathology and abnormal brain barriers in the immunopathogenesis of neuropsychiatric lupus. Nevertheless, there are some discrepancies between the experimental evidence, or its interpretation, and the working hypotheses prevalent in this field; specifically, that a primary contributor to neuropsychiatric disease in lupus is permeabilization of the blood brain barrier. In this commonly held view, any contribution of the other known brain barriers, including the blood-cerebrospinal fluid and meningeal barriers, is mostly excluded from the discussion. In this review we will shed light on some of the blood brain barrier hypotheses and try to trace their roots. In addition, we will suggest new research directions to allow for confirmation of alternative interpretations of the experimental evidence linking the pathology of intra-cerebral vasculature to the pathogenesis of neuropsychiatric lupus.

Original languageEnglish (US)
Pages (from-to)612-619
Number of pages8
JournalAutoimmunity Reviews
Volume16
Issue number6
DOIs
StatePublished - Jun 1 2017

Keywords

  • Blood-brain-barrier
  • Blood-CSF barrier
  • Choroid plexus
  • Glymphatics
  • Neuropsychiatric lupus
  • SLE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface'. Together they form a unique fingerprint.

  • Cite this