The blood brain barrier and neuropsychiatric lupus

new perspectives in light of advances in understanding the neuroimmune interface

Ariel D. Stock, Sivan Gelb, Ofer Pasternak, Ayal Ben-Zvi, Chaim Putterman

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Experts have previously postulated a linkage between lupus associated vascular pathology and abnormal brain barriers in the immunopathogenesis of neuropsychiatric lupus. Nevertheless, there are some discrepancies between the experimental evidence, or its interpretation, and the working hypotheses prevalent in this field; specifically, that a primary contributor to neuropsychiatric disease in lupus is permeabilization of the blood brain barrier. In this commonly held view, any contribution of the other known brain barriers, including the blood-cerebrospinal fluid and meningeal barriers, is mostly excluded from the discussion. In this review we will shed light on some of the blood brain barrier hypotheses and try to trace their roots. In addition, we will suggest new research directions to allow for confirmation of alternative interpretations of the experimental evidence linking the pathology of intra-cerebral vasculature to the pathogenesis of neuropsychiatric lupus.

Original languageEnglish (US)
Pages (from-to)612-619
Number of pages8
JournalAutoimmunity Reviews
Volume16
Issue number6
DOIs
StatePublished - Jun 1 2017

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Blood-Brain Barrier
Pathology
Blood Vessels
Cerebrospinal Fluid
Brain
Research

Keywords

  • Blood-brain-barrier
  • Blood-CSF barrier
  • Choroid plexus
  • Glymphatics
  • Neuropsychiatric lupus
  • SLE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The blood brain barrier and neuropsychiatric lupus : new perspectives in light of advances in understanding the neuroimmune interface. / Stock, Ariel D.; Gelb, Sivan; Pasternak, Ofer; Ben-Zvi, Ayal; Putterman, Chaim.

In: Autoimmunity Reviews, Vol. 16, No. 6, 01.06.2017, p. 612-619.

Research output: Contribution to journalReview article

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