The association of HIV infection with left ventricular mass/hypertrophy

Ather Mansoor, Elizabeth T. Golub, Jack Dehovitz, Kathryn Anastos, Robert C. Kaplan, Jason M. Lazar

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Left ventricular hypertrophy (LVH) is an independent predictor of major cardiovascular events. Cardiovascular risk is increased among human immunodeficiency virus (HIV)-infected patients. To assess LV mass/hypertrophy in HIV infection, 654 women enrolled in the Women's Interagency HIV Study underwent transthoracic echocardiography. There were 454 HIV-infected and 200 uninfected women, mean age 40.8 ± 9.3 years. LV mass/height 2.7 was similar between the HIV-infected and the HIV-uninfected groups (41.4 ± 11.1 vs. 39.9 ± 10.3 g/h 2.7; p = 0.37). The prevalence of LVH was similar between the two groups (LVH by LV mass/height 2.7 criteria 15.0% vs. 13.0%, p = 0.29). Relative wall thickness (RWT), defined as the ratio of LV wall thickness to cavity diameter, was also similar between the HIV-infected and HIV-uninfected groups (0.36 ± 0.05 vs. 0.37 ± 0.06, p=0.16). On multiple linear regression analysis adjusting for age, W/H ratio, triceps skinfold thickness, systolic/diastolic BP, diabetes, hypertension and dyslipidemia; HIV status (b=2.08, p=0.02, CI 0.27-3.88); weight (b per kg=0.15, p<0.01, CI 0.08-0.22); and smoking duration (b per one-year increase=0.08, p=0.03, CI 0.01-0.16) were independent correlates of LV mass/height 2.7 (Model R 2=0.20, p<0.001). Weight (aOR=1.04, CI 1.01-1.06) and smoking duration (aOR=1.03, CI 1.01-1.06) were independent correlates of LVH. Being HIV negative, increased age, increased triceps skinfold thickness, and higher W/H ratio were independent correlates of higher RWT. Among HIV-infected women, higher LV mass was not associated with a history of AIDS-defining illness, nadir CD4 + count <200cells/μl, or with the duration of highly active antiretroviral therapy (HAART). Women taking NRTIs had higher LV mass. Higher RWT was associated with current CD4 + count. In conclusion, HIV infection is associated with greater LV mass but not with a higher prevalence of LVH. Among HIV-infected women, RWT, but not LV mass, is associated with the degree of immunosuppression.

Original languageEnglish (US)
Pages (from-to)475-481
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume25
Issue number5
DOIs
StatePublished - May 1 2009

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Left Ventricular Hypertrophy
Virus Diseases
HIV
Skinfold Thickness
CD4 Lymphocyte Count
Smoking
Weights and Measures
Highly Active Antiretroviral Therapy
Dyslipidemias
Immunosuppression
Hypertrophy
Echocardiography
Linear Models
Acquired Immunodeficiency Syndrome
Regression Analysis

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

The association of HIV infection with left ventricular mass/hypertrophy. / Mansoor, Ather; Golub, Elizabeth T.; Dehovitz, Jack; Anastos, Kathryn; Kaplan, Robert C.; Lazar, Jason M.

In: AIDS Research and Human Retroviruses, Vol. 25, No. 5, 01.05.2009, p. 475-481.

Research output: Contribution to journalArticle

Mansoor, Ather ; Golub, Elizabeth T. ; Dehovitz, Jack ; Anastos, Kathryn ; Kaplan, Robert C. ; Lazar, Jason M. / The association of HIV infection with left ventricular mass/hypertrophy. In: AIDS Research and Human Retroviruses. 2009 ; Vol. 25, No. 5. pp. 475-481.
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abstract = "Left ventricular hypertrophy (LVH) is an independent predictor of major cardiovascular events. Cardiovascular risk is increased among human immunodeficiency virus (HIV)-infected patients. To assess LV mass/hypertrophy in HIV infection, 654 women enrolled in the Women's Interagency HIV Study underwent transthoracic echocardiography. There were 454 HIV-infected and 200 uninfected women, mean age 40.8 ± 9.3 years. LV mass/height 2.7 was similar between the HIV-infected and the HIV-uninfected groups (41.4 ± 11.1 vs. 39.9 ± 10.3 g/h 2.7; p = 0.37). The prevalence of LVH was similar between the two groups (LVH by LV mass/height 2.7 criteria 15.0{\%} vs. 13.0{\%}, p = 0.29). Relative wall thickness (RWT), defined as the ratio of LV wall thickness to cavity diameter, was also similar between the HIV-infected and HIV-uninfected groups (0.36 ± 0.05 vs. 0.37 ± 0.06, p=0.16). On multiple linear regression analysis adjusting for age, W/H ratio, triceps skinfold thickness, systolic/diastolic BP, diabetes, hypertension and dyslipidemia; HIV status (b=2.08, p=0.02, CI 0.27-3.88); weight (b per kg=0.15, p<0.01, CI 0.08-0.22); and smoking duration (b per one-year increase=0.08, p=0.03, CI 0.01-0.16) were independent correlates of LV mass/height 2.7 (Model R 2=0.20, p<0.001). Weight (aOR=1.04, CI 1.01-1.06) and smoking duration (aOR=1.03, CI 1.01-1.06) were independent correlates of LVH. Being HIV negative, increased age, increased triceps skinfold thickness, and higher W/H ratio were independent correlates of higher RWT. Among HIV-infected women, higher LV mass was not associated with a history of AIDS-defining illness, nadir CD4 + count <200cells/μl, or with the duration of highly active antiretroviral therapy (HAART). Women taking NRTIs had higher LV mass. Higher RWT was associated with current CD4 + count. In conclusion, HIV infection is associated with greater LV mass but not with a higher prevalence of LVH. Among HIV-infected women, RWT, but not LV mass, is associated with the degree of immunosuppression.",
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N2 - Left ventricular hypertrophy (LVH) is an independent predictor of major cardiovascular events. Cardiovascular risk is increased among human immunodeficiency virus (HIV)-infected patients. To assess LV mass/hypertrophy in HIV infection, 654 women enrolled in the Women's Interagency HIV Study underwent transthoracic echocardiography. There were 454 HIV-infected and 200 uninfected women, mean age 40.8 ± 9.3 years. LV mass/height 2.7 was similar between the HIV-infected and the HIV-uninfected groups (41.4 ± 11.1 vs. 39.9 ± 10.3 g/h 2.7; p = 0.37). The prevalence of LVH was similar between the two groups (LVH by LV mass/height 2.7 criteria 15.0% vs. 13.0%, p = 0.29). Relative wall thickness (RWT), defined as the ratio of LV wall thickness to cavity diameter, was also similar between the HIV-infected and HIV-uninfected groups (0.36 ± 0.05 vs. 0.37 ± 0.06, p=0.16). On multiple linear regression analysis adjusting for age, W/H ratio, triceps skinfold thickness, systolic/diastolic BP, diabetes, hypertension and dyslipidemia; HIV status (b=2.08, p=0.02, CI 0.27-3.88); weight (b per kg=0.15, p<0.01, CI 0.08-0.22); and smoking duration (b per one-year increase=0.08, p=0.03, CI 0.01-0.16) were independent correlates of LV mass/height 2.7 (Model R 2=0.20, p<0.001). Weight (aOR=1.04, CI 1.01-1.06) and smoking duration (aOR=1.03, CI 1.01-1.06) were independent correlates of LVH. Being HIV negative, increased age, increased triceps skinfold thickness, and higher W/H ratio were independent correlates of higher RWT. Among HIV-infected women, higher LV mass was not associated with a history of AIDS-defining illness, nadir CD4 + count <200cells/μl, or with the duration of highly active antiretroviral therapy (HAART). Women taking NRTIs had higher LV mass. Higher RWT was associated with current CD4 + count. In conclusion, HIV infection is associated with greater LV mass but not with a higher prevalence of LVH. Among HIV-infected women, RWT, but not LV mass, is associated with the degree of immunosuppression.

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