The ARUBA trial: Current status, future hopes

J. P. Mohr, Alan J. Moskowitz, Christian Stapf, Andreas Hartmann, Karen Lord, Steven M. Marshall, Henning Mast, Ellen Moquete, Claudia Scala Moy, Michael Parides, John Pile-Spellman, Rustam Al-Shahi Salman, Alan Weinberg, William L. Young, Alejandrina Estevez, Inam Kureshi, Jonathan L. Brisman

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

Background and Purpose-: Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations. Summary of Review-: Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial. Conclusions-: ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.

Original languageEnglish (US)
Pages (from-to)e537-e540
JournalStroke
Volume41
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • arteriovenous malformations
  • endovascular treatment
  • neuroradiology
  • neurosurgery
  • radiotherapy
  • randomized controlled trials

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Mohr, J. P., Moskowitz, A. J., Stapf, C., Hartmann, A., Lord, K., Marshall, S. M., Mast, H., Moquete, E., Moy, C. S., Parides, M., Pile-Spellman, J., Al-Shahi Salman, R., Weinberg, A., Young, W. L., Estevez, A., Kureshi, I., & Brisman, J. L. (2010). The ARUBA trial: Current status, future hopes. Stroke, 41(8), e537-e540. https://doi.org/10.1161/STROKEAHA.110.580274