The ARUBA trial: Current status, future hopes

J. P. Mohr; Alan J. Moskowitz; Christian Stapf; Andreas Hartmann; Karen Lord; Steven M. Marshall; Henning Mast; Ellen Moquete; Claudia Scala Moy; Michael Parides; John Pile-Spellman; Rustam Al-Shahi Salman; Alan Weinberg; William L. Young; Alejandrina Estevez; Inam Kureshi; Jonathan L. Brisman

doi:10.1161/STROKEAHA.110.580274

The ARUBA trial: Current status, future hopes

J. P. Mohr, Alan J. Moskowitz, Christian Stapf, Andreas Hartmann, Karen Lord, Steven M. Marshall, Henning Mast, Ellen Moquete, Claudia Scala Moy, Michael Parides, John Pile-Spellman, Rustam Al-Shahi Salman, Alan Weinberg, William L. Young, Alejandrina Estevez, Inam Kureshi, Jonathan L. Brisman

Research output: Contribution to journal › Review article › peer-review

72 Scopus citations

Abstract

Background and Purpose-: Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations. Summary of Review-: Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial. Conclusions-: ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.

Original language	English (US)
Pages (from-to)	e537-e540
Journal	Stroke
Volume	41
Issue number	8
DOIs	https://doi.org/10.1161/STROKEAHA.110.580274
State	Published - Aug 2010
Externally published	Yes

Keywords

arteriovenous malformations
endovascular treatment
neuroradiology
neurosurgery
radiotherapy
randomized controlled trials

ASJC Scopus subject areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

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10.1161/STROKEAHA.110.580274

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title = "The ARUBA trial: Current status, future hopes",

abstract = "Background and Purpose-: Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations. Summary of Review-: Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial. Conclusions-: ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.",

keywords = "arteriovenous malformations, endovascular treatment, neuroradiology, neurosurgery, radiotherapy, randomized controlled trials",

author = "Mohr, {J. P.} and Moskowitz, {Alan J.} and Christian Stapf and Andreas Hartmann and Karen Lord and Marshall, {Steven M.} and Henning Mast and Ellen Moquete and Moy, {Claudia Scala} and Michael Parides and John Pile-Spellman and {Al-Shahi Salman}, Rustam and Alan Weinberg and Young, {William L.} and Alejandrina Estevez and Inam Kureshi and Brisman, {Jonathan L.}",

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AU - Mohr, J. P.

AU - Moskowitz, Alan J.

AU - Stapf, Christian

AU - Hartmann, Andreas

AU - Lord, Karen

AU - Marshall, Steven M.

AU - Mast, Henning

AU - Moquete, Ellen

AU - Moy, Claudia Scala

AU - Parides, Michael

AU - Pile-Spellman, John

AU - Al-Shahi Salman, Rustam

AU - Weinberg, Alan

AU - Young, William L.

AU - Estevez, Alejandrina

AU - Kureshi, Inam

AU - Brisman, Jonathan L.

PY - 2010/8

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N2 - Background and Purpose-: Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations. Summary of Review-: Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial. Conclusions-: ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.

AB - Background and Purpose-: Report on the status of an on-going National Institutes of Neurological Disorders and Stroke (NINDS)-supported clinical trial of management of unbled brain arteriovenous malformations. Summary of Review-: Begun in April 2007 with 3 centers, the trial has grown to 65 centers, and has randomized 124 patients through mid-June 2010 en route to the planned 400. The current literature continues to support the rationale for the trial. Conclusions-: ARUBA is steadily approaching its monthly randomization goals and has already reached the number needed to test the maximum published interventional complication rates against the minimum hemorrhage rates for natural history.

KW - arteriovenous malformations

KW - endovascular treatment

KW - neuroradiology

KW - neurosurgery

KW - radiotherapy

KW - randomized controlled trials

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JF - Stroke

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ER -

The ARUBA trial: Current status, future hopes

Abstract

Keywords

ASJC Scopus subject areas

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