The antidepressant trans-2-phenylcyclopropylamine protects mice from high-fat-diet-induced obesity

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mice treated with the antidepressant trans-2-phenylcyclopropylamine (2-PCPA) were protected against diet-induced-obesity, and adiposity was reversed in pre-established diet-induced obese mice. Contrary to a recent report that inhibition of lysine-specific demethylase-1 by 2-PCPA results in increased energy expenditure, long-term 2-PCPA treatment had no such effect but its protection against obesity was associated with increased spontaneous locomotor activity, Moreover, pair feeding to assure equal caloric intake in wild type mice as well as in genetic hyperphagic mice (ob/ob) also resulted in weight reduction in 2-PCPA treated mice that correlated with increased activity but no change in energy expenditure. Similarly, short-term intraperitoneal injections of 2-PCPA did not affect food intake but caused a substantial increase in locomotor activity in the light cycle that correlated with increased energy expenditure, whereas activity and energy expenditure were unchanged in the dark cycle. Lastly, 2-PCPA was also effective in reducing obesity in genetic UCP1 null mice. These data suggest that 2-PCPA can reduce obesity by decreasing food intake in the long term while increasing activity in the short-term. However, the protective and weight loss effects of 2-PCPA are independent of UCP1-regulated thermogenesis or basal energy expenditure.

Original languageEnglish (US)
Article numbere89199
JournalPLoS One
Volume9
Issue number2
DOIs
StatePublished - Feb 21 2014

Fingerprint

Tranylcypromine
antidepressants
High Fat Diet
high fat diet
Nutrition
Energy Metabolism
Antidepressive Agents
obesity
energy expenditure
Obesity
Fats
mice
Locomotion
Weight Loss
Eating
locomotion
food intake
Diet
weight loss
Obese Mice

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The antidepressant trans-2-phenylcyclopropylamine protects mice from high-fat-diet-induced obesity. / Shemesh, Adi; Abdulla, Arian; Yang, Fajun; Chua, Jr., Streamson C.; Pessin, Jeffrey E.; Zong, Haihong.

In: PLoS One, Vol. 9, No. 2, e89199, 21.02.2014.

Research output: Contribution to journalArticle

@article{1fb4469987a04045b088173aa852be7a,
title = "The antidepressant trans-2-phenylcyclopropylamine protects mice from high-fat-diet-induced obesity",
abstract = "Mice treated with the antidepressant trans-2-phenylcyclopropylamine (2-PCPA) were protected against diet-induced-obesity, and adiposity was reversed in pre-established diet-induced obese mice. Contrary to a recent report that inhibition of lysine-specific demethylase-1 by 2-PCPA results in increased energy expenditure, long-term 2-PCPA treatment had no such effect but its protection against obesity was associated with increased spontaneous locomotor activity, Moreover, pair feeding to assure equal caloric intake in wild type mice as well as in genetic hyperphagic mice (ob/ob) also resulted in weight reduction in 2-PCPA treated mice that correlated with increased activity but no change in energy expenditure. Similarly, short-term intraperitoneal injections of 2-PCPA did not affect food intake but caused a substantial increase in locomotor activity in the light cycle that correlated with increased energy expenditure, whereas activity and energy expenditure were unchanged in the dark cycle. Lastly, 2-PCPA was also effective in reducing obesity in genetic UCP1 null mice. These data suggest that 2-PCPA can reduce obesity by decreasing food intake in the long term while increasing activity in the short-term. However, the protective and weight loss effects of 2-PCPA are independent of UCP1-regulated thermogenesis or basal energy expenditure.",
author = "Adi Shemesh and Arian Abdulla and Fajun Yang and {Chua, Jr.}, {Streamson C.} and Pessin, {Jeffrey E.} and Haihong Zong",
year = "2014",
month = "2",
day = "21",
doi = "10.1371/journal.pone.0089199",
language = "English (US)",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - The antidepressant trans-2-phenylcyclopropylamine protects mice from high-fat-diet-induced obesity

AU - Shemesh, Adi

AU - Abdulla, Arian

AU - Yang, Fajun

AU - Chua, Jr., Streamson C.

AU - Pessin, Jeffrey E.

AU - Zong, Haihong

PY - 2014/2/21

Y1 - 2014/2/21

N2 - Mice treated with the antidepressant trans-2-phenylcyclopropylamine (2-PCPA) were protected against diet-induced-obesity, and adiposity was reversed in pre-established diet-induced obese mice. Contrary to a recent report that inhibition of lysine-specific demethylase-1 by 2-PCPA results in increased energy expenditure, long-term 2-PCPA treatment had no such effect but its protection against obesity was associated with increased spontaneous locomotor activity, Moreover, pair feeding to assure equal caloric intake in wild type mice as well as in genetic hyperphagic mice (ob/ob) also resulted in weight reduction in 2-PCPA treated mice that correlated with increased activity but no change in energy expenditure. Similarly, short-term intraperitoneal injections of 2-PCPA did not affect food intake but caused a substantial increase in locomotor activity in the light cycle that correlated with increased energy expenditure, whereas activity and energy expenditure were unchanged in the dark cycle. Lastly, 2-PCPA was also effective in reducing obesity in genetic UCP1 null mice. These data suggest that 2-PCPA can reduce obesity by decreasing food intake in the long term while increasing activity in the short-term. However, the protective and weight loss effects of 2-PCPA are independent of UCP1-regulated thermogenesis or basal energy expenditure.

AB - Mice treated with the antidepressant trans-2-phenylcyclopropylamine (2-PCPA) were protected against diet-induced-obesity, and adiposity was reversed in pre-established diet-induced obese mice. Contrary to a recent report that inhibition of lysine-specific demethylase-1 by 2-PCPA results in increased energy expenditure, long-term 2-PCPA treatment had no such effect but its protection against obesity was associated with increased spontaneous locomotor activity, Moreover, pair feeding to assure equal caloric intake in wild type mice as well as in genetic hyperphagic mice (ob/ob) also resulted in weight reduction in 2-PCPA treated mice that correlated with increased activity but no change in energy expenditure. Similarly, short-term intraperitoneal injections of 2-PCPA did not affect food intake but caused a substantial increase in locomotor activity in the light cycle that correlated with increased energy expenditure, whereas activity and energy expenditure were unchanged in the dark cycle. Lastly, 2-PCPA was also effective in reducing obesity in genetic UCP1 null mice. These data suggest that 2-PCPA can reduce obesity by decreasing food intake in the long term while increasing activity in the short-term. However, the protective and weight loss effects of 2-PCPA are independent of UCP1-regulated thermogenesis or basal energy expenditure.

UR - http://www.scopus.com/inward/record.url?scp=84896743958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896743958&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0089199

DO - 10.1371/journal.pone.0089199

M3 - Article

C2 - 24586592

AN - SCOPUS:84896743958

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 2

M1 - e89199

ER -