The anatomy and pathophysiology of the microvasculature in different organs: relationship to vasculogenic necrosis and tissue damage.

J. G. Jones, S. Cho, S. M. Factor

Research output: Contribution to journalArticle

Abstract

This chapter presents the methodology as well as various applications of a silicone rubber (Microfil) prefusion technique for evaluation of the microcirculation. In the heart, Microfil perfusion has been used in conjunction with clearing techniques to elucidate normal anatomic relationships, to identify areas of myocardium at risk following vascular occlusion, and to observe dynamic events in the development of various cardiomyopathies. Advantages of the technique include in vivo applicability, ease of vascular filling, and ability to discriminate between adjacent vascular fields. Preliminary data from work in other organ systems including skeletal muscle, brain, liver, and lung are also presented.

Original languageEnglish (US)
Pages (from-to)114-143
Number of pages30
JournalMethods and achievements in experimental pathology
Volume13
StatePublished - 1988

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Silicone Elastomers
Microvessels
Blood Vessels
Anatomy
Necrosis
Microcirculation
Cardiomyopathies
Myocardium
Skeletal Muscle
Perfusion
Lung
Liver
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The anatomy and pathophysiology of the microvasculature in different organs : relationship to vasculogenic necrosis and tissue damage. / Jones, J. G.; Cho, S.; Factor, S. M.

In: Methods and achievements in experimental pathology, Vol. 13, 1988, p. 114-143.

Research output: Contribution to journalArticle

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