The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays

Robert J. Kipnis, Joe Craft, John A. Hardin

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

We have characterized autoantibodies to nuclear and nucleolar antigens in 112 patients with diffuse scleroderma, CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias), scleroderma overlap syndromes, or primary Raynaud's phenomenon by indirect immunofluorescence and radiolabeled immunoprecipitation assays. We noted for the first time that anti-Th RNP antibodies represent a common antibody specificity in scleroderma (occurring in 13% of patients with scleroderma-like illnesses) and that anti-NOR 90 antibodies are quite rare in American patients (none found). In addition, we describe 3 new scleroderma-associated autoantibodies.

Original languageEnglish (US)
Pages (from-to)1431-1437
Number of pages7
JournalArthritis and Rheumatism
Volume33
Issue number9
StatePublished - Sep 1990
Externally publishedYes

Fingerprint

Radioimmunoprecipitation Assay
Autoantibodies
Raynaud Disease
CREST Syndrome
Esophageal Motility Disorders
Calcinosis
Diffuse Scleroderma
Telangiectasis
Nuclear Antigens
Antibody Specificity
Antibodies
Indirect Fluorescent Antibody Technique
Immunoprecipitation

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays. / Kipnis, Robert J.; Craft, Joe; Hardin, John A.

In: Arthritis and Rheumatism, Vol. 33, No. 9, 09.1990, p. 1431-1437.

Research output: Contribution to journalArticle

Kipnis, Robert J. ; Craft, Joe ; Hardin, John A. / The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays. In: Arthritis and Rheumatism. 1990 ; Vol. 33, No. 9. pp. 1431-1437.
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