The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays

Robert J. Kipnis, Joe Craft, John A. Hardin

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

We have characterized autoantibodies to nuclear and nucleolar antigens in 112 patients with diffuse scleroderma, CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias), scleroderma overlap syndromes, or primary Raynaud's phenomenon by indirect immunofluo‐rescence and radiolabeled immunoprecipitation assays. We noted for the first time that anti‐Th RNP antibodies represent a common antibody specificity in scleroderma (occurring in 13% of patients with scleroderma‐like illnesses) and that anti‐NOR 90 antibodies are quite rare in American patients (none found). In addition, we describe 3 new scleroderma‐associated autoantibodies.

Original languageEnglish (US)
Pages (from-to)1431-1437
Number of pages7
JournalArthritis & Rheumatism
Volume33
Issue number9
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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