TY - JOUR
T1 - The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays
AU - Kipnis, Robert J.
AU - Craft, Joe
AU - Hardin, John A.
PY - 1990/9
Y1 - 1990/9
N2 - We have characterized autoantibodies to nuclear and nucleolar antigens in 112 patients with diffuse scleroderma, CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias), scleroderma overlap syndromes, or primary Raynaud's phenomenon by indirect immunofluo‐rescence and radiolabeled immunoprecipitation assays. We noted for the first time that anti‐Th RNP antibodies represent a common antibody specificity in scleroderma (occurring in 13% of patients with scleroderma‐like illnesses) and that anti‐NOR 90 antibodies are quite rare in American patients (none found). In addition, we describe 3 new scleroderma‐associated autoantibodies.
AB - We have characterized autoantibodies to nuclear and nucleolar antigens in 112 patients with diffuse scleroderma, CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias), scleroderma overlap syndromes, or primary Raynaud's phenomenon by indirect immunofluo‐rescence and radiolabeled immunoprecipitation assays. We noted for the first time that anti‐Th RNP antibodies represent a common antibody specificity in scleroderma (occurring in 13% of patients with scleroderma‐like illnesses) and that anti‐NOR 90 antibodies are quite rare in American patients (none found). In addition, we describe 3 new scleroderma‐associated autoantibodies.
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U2 - 10.1002/art.1780330917
DO - 10.1002/art.1780330917
M3 - Article
C2 - 2403405
AN - SCOPUS:0025049254
SN - 2326-5191
VL - 33
SP - 1431
EP - 1437
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
IS - 9
ER -