The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women: The Women's Health Initiative Observational Study

Unab I. Khan, Alexandra D. Ogorodnikova, Linzhi Xu, Dan Wang, Sylvia Wassertheil-Smoller, Gloria Y F Ho, Mary Fran R Sowers, Swapnil N. Rajpathak, Matthew A. Allison, Rachel H. Mackey, Mara Z. Vitolins, Joann E. Manson, Rachel P. Wildman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective Nearly, a third of obese individuals, termed metabolically benign obese, have a low burden of adiposity-related cardiometabolic abnormalities, whereas a substantial proportion of normal-weight individuals possess risk factors. Methods In cross-sectional analyses of 699 normal weight and 1,294 overweight/obese postmenopausal women enrolled in a nested case-control stroke study ancillary to the Women's Health Initiative Observational Study, we compared levels of adiponectin, leptin, and resistin among metabolically benign normal weight, at-risk normal weight, metabolically benign obese, and at-risk obese women using components of the ATP III definition of the metabolic syndrome (metabolically benign: ≤1 of the four components; at-risk phenotype: ≥2 components or diabetes). Results Overall, 382/699 normal-weight women (54.6%) and 328/1,194 overweight/obese women (27.5%) were metabolically benign. Among normal-weight women, at-risk women had higher leptin and lower adiponectin levels compared to metabolically benign women; multivariate-adjusted odds ratios were significant for having leptin (OR: 2.51; 95% CI: 1.28-5.01) and resistin (1.46; 1.03-2.07) in the top tertile and adiponectin in the bottom tertile (2.64; 1.81-3.84). Compared to metabolically benign overweight/obese women, at-risk obese women had higher odds of having leptin in the top tertile (1.62; 1.24-2.12) and adiponectin in the bottom tertile (2.78; 2.04-3.77). Conclusions Overall, metabolically benign overweight/obese women had an intermediate adipokine profile (between at-risk obese and metabolically benign normal-weight women), whereas at-risk normal-weight women had a less favorable profile compared to metabolically benign normal-weight women. As adiponectin was the only adipokine independent of BMI, it may be most likely to have a role in the etiological pathway of these phenotypes.

Original languageEnglish (US)
Pages (from-to)786-794
Number of pages9
JournalObesity
Volume22
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Adipokines
Women's Health
Observational Studies
Weights and Measures
Adiponectin
Leptin
Resistin
Phenotype
Adiposity
Case-Control Studies

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Khan, U. I., Ogorodnikova, A. D., Xu, L., Wang, D., Wassertheil-Smoller, S., Ho, G. Y. F., ... Wildman, R. P. (2014). The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women: The Women's Health Initiative Observational Study. Obesity, 22(3), 786-794. https://doi.org/10.1002/oby.20139

The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women : The Women's Health Initiative Observational Study. / Khan, Unab I.; Ogorodnikova, Alexandra D.; Xu, Linzhi; Wang, Dan; Wassertheil-Smoller, Sylvia; Ho, Gloria Y F; Sowers, Mary Fran R; Rajpathak, Swapnil N.; Allison, Matthew A.; Mackey, Rachel H.; Vitolins, Mara Z.; Manson, Joann E.; Wildman, Rachel P.

In: Obesity, Vol. 22, No. 3, 2014, p. 786-794.

Research output: Contribution to journalArticle

Khan, UI, Ogorodnikova, AD, Xu, L, Wang, D, Wassertheil-Smoller, S, Ho, GYF, Sowers, MFR, Rajpathak, SN, Allison, MA, Mackey, RH, Vitolins, MZ, Manson, JE & Wildman, RP 2014, 'The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women: The Women's Health Initiative Observational Study', Obesity, vol. 22, no. 3, pp. 786-794. https://doi.org/10.1002/oby.20139
Khan, Unab I. ; Ogorodnikova, Alexandra D. ; Xu, Linzhi ; Wang, Dan ; Wassertheil-Smoller, Sylvia ; Ho, Gloria Y F ; Sowers, Mary Fran R ; Rajpathak, Swapnil N. ; Allison, Matthew A. ; Mackey, Rachel H. ; Vitolins, Mara Z. ; Manson, Joann E. ; Wildman, Rachel P. / The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women : The Women's Health Initiative Observational Study. In: Obesity. 2014 ; Vol. 22, No. 3. pp. 786-794.
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abstract = "Objective Nearly, a third of obese individuals, termed metabolically benign obese, have a low burden of adiposity-related cardiometabolic abnormalities, whereas a substantial proportion of normal-weight individuals possess risk factors. Methods In cross-sectional analyses of 699 normal weight and 1,294 overweight/obese postmenopausal women enrolled in a nested case-control stroke study ancillary to the Women's Health Initiative Observational Study, we compared levels of adiponectin, leptin, and resistin among metabolically benign normal weight, at-risk normal weight, metabolically benign obese, and at-risk obese women using components of the ATP III definition of the metabolic syndrome (metabolically benign: ≤1 of the four components; at-risk phenotype: ≥2 components or diabetes). Results Overall, 382/699 normal-weight women (54.6{\%}) and 328/1,194 overweight/obese women (27.5{\%}) were metabolically benign. Among normal-weight women, at-risk women had higher leptin and lower adiponectin levels compared to metabolically benign women; multivariate-adjusted odds ratios were significant for having leptin (OR: 2.51; 95{\%} CI: 1.28-5.01) and resistin (1.46; 1.03-2.07) in the top tertile and adiponectin in the bottom tertile (2.64; 1.81-3.84). Compared to metabolically benign overweight/obese women, at-risk obese women had higher odds of having leptin in the top tertile (1.62; 1.24-2.12) and adiponectin in the bottom tertile (2.78; 2.04-3.77). Conclusions Overall, metabolically benign overweight/obese women had an intermediate adipokine profile (between at-risk obese and metabolically benign normal-weight women), whereas at-risk normal-weight women had a less favorable profile compared to metabolically benign normal-weight women. As adiponectin was the only adipokine independent of BMI, it may be most likely to have a role in the etiological pathway of these phenotypes.",
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T1 - The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women

T2 - The Women's Health Initiative Observational Study

AU - Khan, Unab I.

AU - Ogorodnikova, Alexandra D.

AU - Xu, Linzhi

AU - Wang, Dan

AU - Wassertheil-Smoller, Sylvia

AU - Ho, Gloria Y F

AU - Sowers, Mary Fran R

AU - Rajpathak, Swapnil N.

AU - Allison, Matthew A.

AU - Mackey, Rachel H.

AU - Vitolins, Mara Z.

AU - Manson, Joann E.

AU - Wildman, Rachel P.

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N2 - Objective Nearly, a third of obese individuals, termed metabolically benign obese, have a low burden of adiposity-related cardiometabolic abnormalities, whereas a substantial proportion of normal-weight individuals possess risk factors. Methods In cross-sectional analyses of 699 normal weight and 1,294 overweight/obese postmenopausal women enrolled in a nested case-control stroke study ancillary to the Women's Health Initiative Observational Study, we compared levels of adiponectin, leptin, and resistin among metabolically benign normal weight, at-risk normal weight, metabolically benign obese, and at-risk obese women using components of the ATP III definition of the metabolic syndrome (metabolically benign: ≤1 of the four components; at-risk phenotype: ≥2 components or diabetes). Results Overall, 382/699 normal-weight women (54.6%) and 328/1,194 overweight/obese women (27.5%) were metabolically benign. Among normal-weight women, at-risk women had higher leptin and lower adiponectin levels compared to metabolically benign women; multivariate-adjusted odds ratios were significant for having leptin (OR: 2.51; 95% CI: 1.28-5.01) and resistin (1.46; 1.03-2.07) in the top tertile and adiponectin in the bottom tertile (2.64; 1.81-3.84). Compared to metabolically benign overweight/obese women, at-risk obese women had higher odds of having leptin in the top tertile (1.62; 1.24-2.12) and adiponectin in the bottom tertile (2.78; 2.04-3.77). Conclusions Overall, metabolically benign overweight/obese women had an intermediate adipokine profile (between at-risk obese and metabolically benign normal-weight women), whereas at-risk normal-weight women had a less favorable profile compared to metabolically benign normal-weight women. As adiponectin was the only adipokine independent of BMI, it may be most likely to have a role in the etiological pathway of these phenotypes.

AB - Objective Nearly, a third of obese individuals, termed metabolically benign obese, have a low burden of adiposity-related cardiometabolic abnormalities, whereas a substantial proportion of normal-weight individuals possess risk factors. Methods In cross-sectional analyses of 699 normal weight and 1,294 overweight/obese postmenopausal women enrolled in a nested case-control stroke study ancillary to the Women's Health Initiative Observational Study, we compared levels of adiponectin, leptin, and resistin among metabolically benign normal weight, at-risk normal weight, metabolically benign obese, and at-risk obese women using components of the ATP III definition of the metabolic syndrome (metabolically benign: ≤1 of the four components; at-risk phenotype: ≥2 components or diabetes). Results Overall, 382/699 normal-weight women (54.6%) and 328/1,194 overweight/obese women (27.5%) were metabolically benign. Among normal-weight women, at-risk women had higher leptin and lower adiponectin levels compared to metabolically benign women; multivariate-adjusted odds ratios were significant for having leptin (OR: 2.51; 95% CI: 1.28-5.01) and resistin (1.46; 1.03-2.07) in the top tertile and adiponectin in the bottom tertile (2.64; 1.81-3.84). Compared to metabolically benign overweight/obese women, at-risk obese women had higher odds of having leptin in the top tertile (1.62; 1.24-2.12) and adiponectin in the bottom tertile (2.78; 2.04-3.77). Conclusions Overall, metabolically benign overweight/obese women had an intermediate adipokine profile (between at-risk obese and metabolically benign normal-weight women), whereas at-risk normal-weight women had a less favorable profile compared to metabolically benign normal-weight women. As adiponectin was the only adipokine independent of BMI, it may be most likely to have a role in the etiological pathway of these phenotypes.

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