Abstract
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 947-953 |
| Number of pages | 7 |
| Journal | Nature Medicine |
| Volume | 7 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 29 2001 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001). The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Medicine, 7(8), 947-953. https://doi.org/10.1038/90992