Abstract
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 947-953 |
| Number of pages | 7 |
| Journal | Nature Medicine |
| Volume | 7 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2001 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. / Berg, Anders H.; Combs, Terry P.; Du, Xue-Liang; Brownlee, Michael; Scherer, Philipp E.
In: Nature Medicine, Vol. 7, No. 8, 2001, p. 947-953.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
AU - Berg, Anders H.
AU - Combs, Terry P.
AU - Du, Xue-Liang
AU - Brownlee, Michael
AU - Scherer, Philipp E.
PY - 2001
Y1 - 2001
N2 - Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
AB - Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
UR - http://www.scopus.com/inward/record.url?scp=0034881391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034881391&partnerID=8YFLogxK
U2 - 10.1038/90992
DO - 10.1038/90992
M3 - Article
C2 - 11479628
AN - SCOPUS:0034881391
VL - 7
SP - 947
EP - 953
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 8
ER -