The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Anders H. Berg, Terry P. Combs, Xue-Liang Du, Michael Brownlee, Philipp E. Scherer

Research output: Contribution to journalArticle

2039 Citations (Scopus)

Abstract

Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.

Original languageEnglish (US)
Pages (from-to)947-953
Number of pages7
JournalNature Medicine
Volume7
Issue number8
DOIs
StatePublished - 2001

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Adipocytes
Insulin
Glucose
Liver
Adipose Tissue
Proteins
Tissue
Streptozocin
Metabolism
Hyperglycemia
Hepatocytes
Injections
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Berg, A. H., Combs, T. P., Du, X-L., Brownlee, M., & Scherer, P. E. (2001). The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Medicine, 7(8), 947-953. https://doi.org/10.1038/90992

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. / Berg, Anders H.; Combs, Terry P.; Du, Xue-Liang; Brownlee, Michael; Scherer, Philipp E.

In: Nature Medicine, Vol. 7, No. 8, 2001, p. 947-953.

Research output: Contribution to journalArticle

Berg, AH, Combs, TP, Du, X-L, Brownlee, M & Scherer, PE 2001, 'The adipocyte-secreted protein Acrp30 enhances hepatic insulin action', Nature Medicine, vol. 7, no. 8, pp. 947-953. https://doi.org/10.1038/90992
Berg, Anders H. ; Combs, Terry P. ; Du, Xue-Liang ; Brownlee, Michael ; Scherer, Philipp E. / The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. In: Nature Medicine. 2001 ; Vol. 7, No. 8. pp. 947-953.
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