Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder

Shugao Xia, Xiaobo Li, Ariane E. Kimball, Mary S. Kelly, Iris Lesser, Craig A. Branch

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural magnetic resonance imaging and diffusion (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between the thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume204
Issue number2-3
DOIs
StatePublished - Nov 30 2012

Fingerprint

Attention Deficit Disorder with Hyperactivity
Thalamus
Executive Function
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Anisotropy
Brain
Atrophy
Hippocampus
White Matter

Keywords

  • ADHD
  • DTI tractography
  • Magnetic resonance imaging (MRI)
  • Shape analysis
  • Thalamus

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder. / Xia, Shugao; Li, Xiaobo; Kimball, Ariane E.; Kelly, Mary S.; Lesser, Iris; Branch, Craig A.

In: Psychiatry Research - Neuroimaging, Vol. 204, No. 2-3, 30.11.2012, p. 161-167.

Research output: Contribution to journalArticle

@article{258d2f4312fc4e3f96f0aa5024a560dd,
title = "Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder",
abstract = "Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural magnetic resonance imaging and diffusion (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between the thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.",
keywords = "ADHD, DTI tractography, Magnetic resonance imaging (MRI), Shape analysis, Thalamus",
author = "Shugao Xia and Xiaobo Li and Kimball, {Ariane E.} and Kelly, {Mary S.} and Iris Lesser and Branch, {Craig A.}",
year = "2012",
month = "11",
day = "30",
doi = "10.1016/j.pscychresns.2012.04.011",
language = "English (US)",
volume = "204",
pages = "161--167",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

TY - JOUR

T1 - Thalamic shape and connectivity abnormalities in children with attention- deficit/hyperactivity disorder

AU - Xia, Shugao

AU - Li, Xiaobo

AU - Kimball, Ariane E.

AU - Kelly, Mary S.

AU - Lesser, Iris

AU - Branch, Craig A.

PY - 2012/11/30

Y1 - 2012/11/30

N2 - Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural magnetic resonance imaging and diffusion (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between the thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.

AB - Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural magnetic resonance imaging and diffusion (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between the thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.

KW - ADHD

KW - DTI tractography

KW - Magnetic resonance imaging (MRI)

KW - Shape analysis

KW - Thalamus

UR - http://www.scopus.com/inward/record.url?scp=84872391121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872391121&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2012.04.011

DO - 10.1016/j.pscychresns.2012.04.011

M3 - Article

C2 - 23149038

AN - SCOPUS:84872391121

VL - 204

SP - 161

EP - 167

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 2-3

ER -