Testosterone treatment and sexual function in older men with low testosterone levels

Glenn R. Cunningham, Alisa J. Stephens-Shields, Raymond C. Rosen, Christina Wang, Shalender Bhasin, Alvin M. Matsumoto, J. Kellogg Parsons, Thomas M. Gill, Mark E. Molitch, John T. Farrar, David Cella, Elizabeth Barrett-Connor, Jane A. Cauley, Denise Cifelli, Jill P. Crandall, Kristine E. Ensrud, Laura Gallagher, Bret Zeldow, Cora E. Lewis, Marco Pahor & 8 others Ronald S. Swerdloff, Xiaoling Hou, Stephen Anton, Shehzad Basaria, Susan J. Diem, Vafa Tabatabaie, Susan S. Ellenberg, Peter J. Snyder

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Context: The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels. Initial results of the Sexual Function Trial showed that T improved sexual activity, sexual desire, and erectile function. Objective: To assess the responsiveness of specific sexual activities to T treatment; to relate hormone changes to changes in sexual function; and to determine predictive baseline characteristics and T threshold for sexual outcomes. Design: A placebo-controlled trial. Setting: Twelve academic medical centers in the United States. Participants: A total of 470 men ≥65 years of age with low libido, average T <275 ng/dL, and a partner willing to have sexual intercourse at least twice a month. Methods: Men were assigned to take T gel or placebo for 1 year. Sexual function was assessed by three questionnaires every 3 months: the Psychosexual Daily Questionnaire, the Derogatis Interview for Sexual Function, and the International Index of Erectile Function. Results: Compared with placebo, T administration significantly improved 10 of 12 measures of sexual activity. Incremental increases in total and free T and estradiol levels were associated with improvements in sexual activityanddesire, but not erectile function.Nothreshold T levelwasobserved for any outcome, and none of the 27 baseline characteristics predicted responsiveness to T. Conclusions: In older men with low libido and low T levels, improvements in sexual desire and activity in response to T treatment were related to the magnitude of increases in T and estradiol levels, but there was no clear evidence of a threshold effect.

Original languageEnglish (US)
Pages (from-to)3096-3104
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number8
DOIs
StatePublished - Aug 1 2016

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Sexual Behavior
Testosterone
Libido
Placebos
Estradiol
Coitus
Therapeutics
Gels
Hormones
Interviews
Surveys and Questionnaires

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Medicine(all)
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Cunningham, G. R., Stephens-Shields, A. J., Rosen, R. C., Wang, C., Bhasin, S., Matsumoto, A. M., ... Snyder, P. J. (2016). Testosterone treatment and sexual function in older men with low testosterone levels. Journal of Clinical Endocrinology and Metabolism, 101(8), 3096-3104. https://doi.org/10.1210/jc.2016-1645

Testosterone treatment and sexual function in older men with low testosterone levels. / Cunningham, Glenn R.; Stephens-Shields, Alisa J.; Rosen, Raymond C.; Wang, Christina; Bhasin, Shalender; Matsumoto, Alvin M.; Parsons, J. Kellogg; Gill, Thomas M.; Molitch, Mark E.; Farrar, John T.; Cella, David; Barrett-Connor, Elizabeth; Cauley, Jane A.; Cifelli, Denise; Crandall, Jill P.; Ensrud, Kristine E.; Gallagher, Laura; Zeldow, Bret; Lewis, Cora E.; Pahor, Marco; Swerdloff, Ronald S.; Hou, Xiaoling; Anton, Stephen; Basaria, Shehzad; Diem, Susan J.; Tabatabaie, Vafa; Ellenberg, Susan S.; Snyder, Peter J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 8, 01.08.2016, p. 3096-3104.

Research output: Contribution to journalArticle

Cunningham, GR, Stephens-Shields, AJ, Rosen, RC, Wang, C, Bhasin, S, Matsumoto, AM, Parsons, JK, Gill, TM, Molitch, ME, Farrar, JT, Cella, D, Barrett-Connor, E, Cauley, JA, Cifelli, D, Crandall, JP, Ensrud, KE, Gallagher, L, Zeldow, B, Lewis, CE, Pahor, M, Swerdloff, RS, Hou, X, Anton, S, Basaria, S, Diem, SJ, Tabatabaie, V, Ellenberg, SS & Snyder, PJ 2016, 'Testosterone treatment and sexual function in older men with low testosterone levels', Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 8, pp. 3096-3104. https://doi.org/10.1210/jc.2016-1645
Cunningham GR, Stephens-Shields AJ, Rosen RC, Wang C, Bhasin S, Matsumoto AM et al. Testosterone treatment and sexual function in older men with low testosterone levels. Journal of Clinical Endocrinology and Metabolism. 2016 Aug 1;101(8):3096-3104. https://doi.org/10.1210/jc.2016-1645
Cunningham, Glenn R. ; Stephens-Shields, Alisa J. ; Rosen, Raymond C. ; Wang, Christina ; Bhasin, Shalender ; Matsumoto, Alvin M. ; Parsons, J. Kellogg ; Gill, Thomas M. ; Molitch, Mark E. ; Farrar, John T. ; Cella, David ; Barrett-Connor, Elizabeth ; Cauley, Jane A. ; Cifelli, Denise ; Crandall, Jill P. ; Ensrud, Kristine E. ; Gallagher, Laura ; Zeldow, Bret ; Lewis, Cora E. ; Pahor, Marco ; Swerdloff, Ronald S. ; Hou, Xiaoling ; Anton, Stephen ; Basaria, Shehzad ; Diem, Susan J. ; Tabatabaie, Vafa ; Ellenberg, Susan S. ; Snyder, Peter J. / Testosterone treatment and sexual function in older men with low testosterone levels. In: Journal of Clinical Endocrinology and Metabolism. 2016 ; Vol. 101, No. 8. pp. 3096-3104.
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abstract = "Context: The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels. Initial results of the Sexual Function Trial showed that T improved sexual activity, sexual desire, and erectile function. Objective: To assess the responsiveness of specific sexual activities to T treatment; to relate hormone changes to changes in sexual function; and to determine predictive baseline characteristics and T threshold for sexual outcomes. Design: A placebo-controlled trial. Setting: Twelve academic medical centers in the United States. Participants: A total of 470 men ≥65 years of age with low libido, average T <275 ng/dL, and a partner willing to have sexual intercourse at least twice a month. Methods: Men were assigned to take T gel or placebo for 1 year. Sexual function was assessed by three questionnaires every 3 months: the Psychosexual Daily Questionnaire, the Derogatis Interview for Sexual Function, and the International Index of Erectile Function. Results: Compared with placebo, T administration significantly improved 10 of 12 measures of sexual activity. Incremental increases in total and free T and estradiol levels were associated with improvements in sexual activityanddesire, but not erectile function.Nothreshold T levelwasobserved for any outcome, and none of the 27 baseline characteristics predicted responsiveness to T. Conclusions: In older men with low libido and low T levels, improvements in sexual desire and activity in response to T treatment were related to the magnitude of increases in T and estradiol levels, but there was no clear evidence of a threshold effect.",
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AU - Cunningham, Glenn R.

AU - Stephens-Shields, Alisa J.

AU - Rosen, Raymond C.

AU - Wang, Christina

AU - Bhasin, Shalender

AU - Matsumoto, Alvin M.

AU - Parsons, J. Kellogg

AU - Gill, Thomas M.

AU - Molitch, Mark E.

AU - Farrar, John T.

AU - Cella, David

AU - Barrett-Connor, Elizabeth

AU - Cauley, Jane A.

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AU - Crandall, Jill P.

AU - Ensrud, Kristine E.

AU - Gallagher, Laura

AU - Zeldow, Bret

AU - Lewis, Cora E.

AU - Pahor, Marco

AU - Swerdloff, Ronald S.

AU - Hou, Xiaoling

AU - Anton, Stephen

AU - Basaria, Shehzad

AU - Diem, Susan J.

AU - Tabatabaie, Vafa

AU - Ellenberg, Susan S.

AU - Snyder, Peter J.

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N2 - Context: The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels. Initial results of the Sexual Function Trial showed that T improved sexual activity, sexual desire, and erectile function. Objective: To assess the responsiveness of specific sexual activities to T treatment; to relate hormone changes to changes in sexual function; and to determine predictive baseline characteristics and T threshold for sexual outcomes. Design: A placebo-controlled trial. Setting: Twelve academic medical centers in the United States. Participants: A total of 470 men ≥65 years of age with low libido, average T <275 ng/dL, and a partner willing to have sexual intercourse at least twice a month. Methods: Men were assigned to take T gel or placebo for 1 year. Sexual function was assessed by three questionnaires every 3 months: the Psychosexual Daily Questionnaire, the Derogatis Interview for Sexual Function, and the International Index of Erectile Function. Results: Compared with placebo, T administration significantly improved 10 of 12 measures of sexual activity. Incremental increases in total and free T and estradiol levels were associated with improvements in sexual activityanddesire, but not erectile function.Nothreshold T levelwasobserved for any outcome, and none of the 27 baseline characteristics predicted responsiveness to T. Conclusions: In older men with low libido and low T levels, improvements in sexual desire and activity in response to T treatment were related to the magnitude of increases in T and estradiol levels, but there was no clear evidence of a threshold effect.

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