Testosterone induction of estero-proteolytic activity in the mouse submaxillary gland

R. A. Angeletti, P. U. Angeletti, P. Calissano

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Testosterone injections sharply increase the estero-proteolytic activity in submaxillary gland extracts of female and of adolescent mice. A major form of hormone-dependent enzyme has been isolated and purified from male gland extracts. The enzyme has a molecular weight of about 32000 and appears to be a peptide hydrolase with strong esterolytic activity. A specific antiserum to the purified enzyme was prepared and used for immunochemical titrations. The results indicate that the increased enzyme activity in the gland following testosterone treatment is due to an increased concentration of enzyme molecules. Incorporation studies gave additional evidence that the hormone stimulates the rate of the enzyme synthesis in the gland.

Original languageEnglish (US)
Pages (from-to)372-381
Number of pages10
JournalBBA - Enzymology
Volume139
Issue number2
StatePublished - Jul 11 1967
Externally publishedYes

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Submandibular Gland
Testosterone
Enzymes
Hormones
Immune Sera
Peptide Hydrolases
Molecular Weight
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Angeletti, R. A., Angeletti, P. U., & Calissano, P. (1967). Testosterone induction of estero-proteolytic activity in the mouse submaxillary gland. BBA - Enzymology, 139(2), 372-381.

Testosterone induction of estero-proteolytic activity in the mouse submaxillary gland. / Angeletti, R. A.; Angeletti, P. U.; Calissano, P.

In: BBA - Enzymology, Vol. 139, No. 2, 11.07.1967, p. 372-381.

Research output: Contribution to journalArticle

Angeletti, RA, Angeletti, PU & Calissano, P 1967, 'Testosterone induction of estero-proteolytic activity in the mouse submaxillary gland' BBA - Enzymology, vol. 139, no. 2, pp. 372-381.
Angeletti RA, Angeletti PU, Calissano P. Testosterone induction of estero-proteolytic activity in the mouse submaxillary gland. BBA - Enzymology. 1967 Jul 11;139(2):372-381.
Angeletti, R. A. ; Angeletti, P. U. ; Calissano, P. / Testosterone induction of estero-proteolytic activity in the mouse submaxillary gland. In: BBA - Enzymology. 1967 ; Vol. 139, No. 2. pp. 372-381.
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