Temporal interrelationships between the circadian rhythms of serum parathyroid hormone and calcium concentrations

Morri E. Markowitz, S. Arnaud, J. F. Rosen, Michael J. Thorpy, S. Laximinarayan

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Abstract

The temporal relationships between the circadian rhythms of serum PTH, total calcium (Ca(t)), and phosphate (Pi) and plasma ionized calcium (Ca(i)) concentrations were determined in 9 normal men. Blood samples were collected every half hour for 24 h. Serum PTH was measured by an RIA specific for the midregion of the molecule. The mean circadian pattern for each variable was derived by calculating the average value across all men at concurrent time points. After the data were smoothed by the method of running means, the correlations between PTH and mineral values from concurrent time points were calculated, as were cross-correlations to 12 lag periods (6 h). Spectral and cross-spectral analyses were performed on the same data set. Both statistical methods yielded consistent results: 1) at concurrent time points (0 lag), high correlations were found between serum PTH and Ca(t) (r = -0.74), PTH and Pi (r = 0.79), and PTH and Ca(i) (r = -0.53); and 2) when the PTH series was lagged by 2 h, the PTH/Ca(i) correlation improved to -0.70. A direct PTH/Ca(i) correlation of 0.50 was found when the Ca(i) series was lagged about 4.5 h. No improvement in the correlations were found when the other series were lagged. Spectral analyses also detected significant interrelations between PTH and Ca(i) at 2 and 3.5 h. These data describe the timing of the bidirectional interaction between serum PTH and plasma Ca(i) under steady state conditions in normal adult men; changes in Ca(i) concentrations precede inverse changes in PTH levels by 2 h, whereas changes in PTH precede similar directional alterations in Ca(i) by about 4 h.

Original languageEnglish (US)
Pages (from-to)1068-1073
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume67
Issue number5
StatePublished - 1988

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Circadian Rhythm
Parathyroid Hormone
Calcium
Plasmas
Beam plasma interactions
Serum
Minerals
Statistical methods
Blood
Phosphates
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Temporal interrelationships between the circadian rhythms of serum parathyroid hormone and calcium concentrations. / Markowitz, Morri E.; Arnaud, S.; Rosen, J. F.; Thorpy, Michael J.; Laximinarayan, S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 67, No. 5, 1988, p. 1068-1073.

Research output: Contribution to journalArticle

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