Telephone screening for amnestic mild cognitive impairment

Christopher R. Lines, Kathleen A. McCarroll, Richard B. Lipton, Gilbert A. Block

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Objectives: To evaluate the utility of telephone screening for identifying subjects with amnestic mild cognitive impairment (aMCI) for enrollment in a clinical trial and to identify which elements of the modified Telephone Interview for Cognitive Status (TICS-m) best predicted the in-clinic determination of aMCI. Methods: Subjects aged ≥65 years with memory complaints responded to an advertisement for a clinical trial by calling a central telephone recruiting agency. To determine eligibility, subjects went through a stepwise selection procedure involving a review of major protocol inclusion and exclusion criteria, followed by administration of the Category Fluency Test (CFT) and then the TICS-m. Subjects meeting entry criteria, who obtained a score of ≤13 on the CFT for "animals" and ≤24 on the CFT for "animals" and "fruits" and who scored between 19 and 38 on the TICS-m, were referred for a clinic appointment to determine whether they met clinical criteria for aMCI. Clinical criteria for aMCI required a score of 24 on the Mini-Mental State Examination and a score ≤37 on the Rey Auditory Verbal Learning Test. A post hoc analysis was performed using factor analysis and logistic regression models to investigate which elements of the TICS-m best predicted the in-clinic determination of aMCI. Results: Of 16,988 subjects who called the telephone agency, 8,742 passed the review of inclusion/exclusion criteria; 6,090 met the CFT cut scores and received the TICS-m; 5,223 met cut scores on the TICS-m and were referred for an in-clinic appointment; 747 were seen in the clinic; and 324 met clinical criteria for aMCI. Factor analysis indicated three factors on the TICS-m: language/attention, orientation, and memory. The memory factor, comprising immediate and delayed recall of a word list, was the most important contributor for identifying subjects who met clinical criteria for aMCI. Conclusion: Only 2% of subjects who underwent telephone screening were recruited into the study, but 43% of those who passed telephone screening and were seen in the clinic met clinical criteria for aMCI. The word recall tests of the TICS-m were the most important items for identifying which subjects met clinical criteria for aMCI.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalNeurology
Volume60
Issue number2
StatePublished - Jan 28 2003

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Telephone
Statistical Factor Analysis
Appointments and Schedules
Logistic Models
Clinical Trials
Cognitive Dysfunction
Verbal Learning
Short-Term Memory
Fruit
Language
Interviews

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lines, C. R., McCarroll, K. A., Lipton, R. B., & Block, G. A. (2003). Telephone screening for amnestic mild cognitive impairment. Neurology, 60(2), 261-266.

Telephone screening for amnestic mild cognitive impairment. / Lines, Christopher R.; McCarroll, Kathleen A.; Lipton, Richard B.; Block, Gilbert A.

In: Neurology, Vol. 60, No. 2, 28.01.2003, p. 261-266.

Research output: Contribution to journalArticle

Lines, CR, McCarroll, KA, Lipton, RB & Block, GA 2003, 'Telephone screening for amnestic mild cognitive impairment', Neurology, vol. 60, no. 2, pp. 261-266.
Lines CR, McCarroll KA, Lipton RB, Block GA. Telephone screening for amnestic mild cognitive impairment. Neurology. 2003 Jan 28;60(2):261-266.
Lines, Christopher R. ; McCarroll, Kathleen A. ; Lipton, Richard B. ; Block, Gilbert A. / Telephone screening for amnestic mild cognitive impairment. In: Neurology. 2003 ; Vol. 60, No. 2. pp. 261-266.
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