TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G1- to S-phase transition

Yi Dong Wang, Guo Hui Bian, Xiao Yan Lv, Rong Zheng, Huan Sun, Zheng Zhang, Ye Chen, Qin Wei Li, Yan Xiao, Qiu Tan Yang, Jian Zhong Ai, Yu Quan Wei, Qin Zhou

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Although previous studies have implicated a role for TC1 (C8orf4) in cancer cell proliferation, the molecular mechanism of its action is still largely unclear. In this study, we showed, for the first time, that the mRNA levels of TC1 were upregulated by mitogens (FBS/thrombin) and at least partially, through the ERK1/2 signaling pathway. Interestingly, the over-expression of TC1 promoted the G1- to S-phase transition of the cell cycle, which was delayed by the deficiency of ERK1/2 signaling in fibroblast cells. Furthermore, the luciferase reporter assay indicated that the over-expression of TC1 significantly increased Cyclin D1 promoter-driven luciferase activity. Taken together, our findings revealed that TC1 was involved in the mitogen-activated ERK1/2 signaling pathway and positively regulated G1- to S-phase transition of the cell cycle. Our results may provide a novel mechanism of the role of TC1 in the regulation of cell proliferation.

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalJournal of Biochemistry and Molecular Biology
Volume41
Issue number10
StatePublished - Oct 1 2008

Keywords

  • Cell proliferation
  • Cyclin D1
  • ERK1/2 signaling pathway
  • G- to S-phase transition
  • TC1 (C8orf4)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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  • Cite this

    Wang, Y. D., Bian, G. H., Lv, X. Y., Zheng, R., Sun, H., Zhang, Z., Chen, Y., Li, Q. W., Xiao, Y., Yang, Q. T., Ai, J. Z., Wei, Y. Q., & Zhou, Q. (2008). TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G1- to S-phase transition. Journal of Biochemistry and Molecular Biology, 41(10), 733-738.