Taxol induced microtubule formations in fibroblasts of fetal mouse dorsal root ganglion-spinal cord cultures

E. B. Masurovsky, E. R. Peterson, S. M. Crain, S. B. Horwitz

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Taxol engenders the formation of two types of unusual ordered arrays of microtubules (MT) in fibroblasts of mouse dorsal root ganglion-spinal cord explant cultures. One consists of lattice-like arrangements of MTs interdigitating with filamentous elements in the cytoplasm. The other of MTs arrayed along endoplasmic reticulum (ER) cisternae at regular ~30 nm intervals. Short linear elements, presumably proteinaceous, extend between the MTs and ER cisternae.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalBiology of the Cell
Issue number2
Publication statusPublished - Jan 1 1982


ASJC Scopus subject areas

  • Cell Biology

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