Targeting cell cycle by β-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer

Imad Ahmad, Sajad Fakhri, Haroon Khan, Philippe Jeandet, Michael Aschner, Zhi Ling Yu

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Cell cycle dysregulation is the mainstay of aberrant cell proliferation, which leads to tumor progression. Mutations in tumor cells initiate various dysregulated pathways and spontaneous over-proliferation with genomic/chromosomal instability. Despite advances in cancer therapy, it has remained a medicinal challenge to treat. Besides, the complexity of pathophysiological pathways behind cancer raises the need for novel multi-target agents, possessing fewer side effects. Alkaloid-based therapies have been explored so far to target cell division in cancer, including vinca alkaloids. As a class of hopeful β-carboline derivatives, growing evidence has indicated their auspicious roles in combating cancer by inhibiting topoisomerase (TOPO), kinesin Eg5, telomerase, cyclin-dependent kinase (CDK), IκB kinase (IKK), and polo-like kinase-1 (PLK1) in the transition phases of cell cycle. In this review, in vitro potential of β-carboline has been revealed through targeting cell division cycle at different phases. In conclusion, β-carboline alkaloids could be introduced as novel candidates in cancer therapy.

Original languageEnglish (US)
Article number109229
JournalChemico-Biological Interactions
Volume330
DOIs
StatePublished - Oct 1 2020

Keywords

  • Alkaloids
  • Cancer treatment
  • Cell cycle
  • Therapeutic potential
  • β-carboline

ASJC Scopus subject areas

  • Toxicology

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