Tailor-made monoclonal antibodies

R. A. DePinho, L. B. Feldman, M. D. Scharff

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Monoclonal antibodies, potentially powerful diagnostic and therapeutic reagents, are having a significant impact in basic and clinical research. Some persisting problems must be solved, however, in order to realize the potential of this technology. We review the basic biology of antibody molecules and the genes that encode them, and discuss how this knowledge can be applied to make more effective monoclonal antibodies.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalAnnals of internal medicine
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Internal Medicine


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