Tailor-made monoclonal antibodies

R. A. DePinho; L. B. Feldman; M. D. Scharff

doi:10.7326/0003-4819-104-2-225

Tailor-made monoclonal antibodies

R. A. DePinho, L. B. Feldman, M. D. Scharff

Cell Biology

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Monoclonal antibodies, potentially powerful diagnostic and therapeutic reagents, are having a significant impact in basic and clinical research. Some persisting problems must be solved, however, in order to realize the potential of this technology. We review the basic biology of antibody molecules and the genes that encode them, and discuss how this knowledge can be applied to make more effective monoclonal antibodies.

Original language	English (US)
Pages (from-to)	225-233
Number of pages	9
Journal	Annals of internal medicine
Volume	104
Issue number	2
DOIs	https://doi.org/10.7326/0003-4819-104-2-225
State	Published - 1986

ASJC Scopus subject areas

Internal Medicine

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10.7326/0003-4819-104-2-225

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title = "Tailor-made monoclonal antibodies",

abstract = "Monoclonal antibodies, potentially powerful diagnostic and therapeutic reagents, are having a significant impact in basic and clinical research. Some persisting problems must be solved, however, in order to realize the potential of this technology. We review the basic biology of antibody molecules and the genes that encode them, and discuss how this knowledge can be applied to make more effective monoclonal antibodies.",

author = "DePinho, {R. A.} and Feldman, {L. B.} and Scharff, {M. D.}",

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AU - Feldman, L. B.

AU - Scharff, M. D.

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N2 - Monoclonal antibodies, potentially powerful diagnostic and therapeutic reagents, are having a significant impact in basic and clinical research. Some persisting problems must be solved, however, in order to realize the potential of this technology. We review the basic biology of antibody molecules and the genes that encode them, and discuss how this knowledge can be applied to make more effective monoclonal antibodies.

AB - Monoclonal antibodies, potentially powerful diagnostic and therapeutic reagents, are having a significant impact in basic and clinical research. Some persisting problems must be solved, however, in order to realize the potential of this technology. We review the basic biology of antibody molecules and the genes that encode them, and discuss how this knowledge can be applied to make more effective monoclonal antibodies.

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M3 - Review article

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JO - Annals of internal medicine

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ER -

Tailor-made monoclonal antibodies

Abstract

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