T-helper type 2 polarization among asthmatics during and following pregnancy

Deepa Rastogi, C. Wang, C. Lendor, P. B. Rothman, R. L. Miller

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Asthma is the most common medical condition during pregnancy. While increased production of T helper cytokines has been reported to occur in both asthma and pregnancy, the effect of T-helper type 2 (Th2) polarization on asthma symptoms during pregnancy has not been well-characterized. Objective: We hypothesized that systemic Th2 cytokine and chemokine polarization occurs among asthmatics to a greater extent during their pregnancy, and is associated with more severe asthma and increased Th2 polarization in the newborn. Methods: Fifty-six pregnant asthmatics were recruited from prenatal clinics affiliated with New York Presbyterian Hospital. Systemic production of interleukin-4, interferon-γ, eotaxin and IP 10 were measured by intracytoplasmic staining or ELISA at recruitment, peripartum and post-partum, and in the cord blood. The frequency of asthma symptoms was measured by questionnaires and compared with Th biomarkers. Results: The chemokine ratio (IP 10/eotaxin) declined over the course of pregnancy (from 3.3 ± 1.3 to 1.4 ±0 .2, P = 0.016), but IP 10 and eotaxin increased post-partum. The decrease in the chemokine ratio was associated with more frequent asthma symptoms. A non-significant trend towards decreased interferon-γ and increased interleukin-4 production was detected. Cord blood eotaxin levels correlated with maternal levels (r = 0.3 5, P = 0.03). Other peripartum biomarkers were not associated with Th2 polarization nor with subsequent respiratory symptoms in the newborn. Conclusions: IP 10/eotaxin declined over the course of pregnancy and was associated with worse asthma symptoms. Alterations of Th1/Th2 chemokine balance during pregnancy may identify women prone to more severe asthma during pregnancy.

Original languageEnglish (US)
Pages (from-to)892-898
Number of pages7
JournalClinical and Experimental Allergy
Volume36
Issue number7
DOIs
StatePublished - Jul 2006

Fingerprint

Asthma
Pregnancy
Chemokines
Peripartum Period
Fetal Blood
Interleukin-4
Interferons
Biomarkers
Newborn Infant
Cytokines
Enzyme-Linked Immunosorbent Assay
Mothers
Staining and Labeling

Keywords

  • Asthma
  • Asthma symptoms
  • Pregnancy
  • T helper chemokines
  • T helper cytokines

ASJC Scopus subject areas

  • Immunology

Cite this

T-helper type 2 polarization among asthmatics during and following pregnancy. / Rastogi, Deepa; Wang, C.; Lendor, C.; Rothman, P. B.; Miller, R. L.

In: Clinical and Experimental Allergy, Vol. 36, No. 7, 07.2006, p. 892-898.

Research output: Contribution to journalArticle

Rastogi, Deepa ; Wang, C. ; Lendor, C. ; Rothman, P. B. ; Miller, R. L. / T-helper type 2 polarization among asthmatics during and following pregnancy. In: Clinical and Experimental Allergy. 2006 ; Vol. 36, No. 7. pp. 892-898.
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