Synthesis of variants of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine

Shih‐Hsi ‐H Chu, Zhi‐Hao ‐H Chen, Zum‐Yao ‐Y Weng, Elizabeth C. Rowe, Edward Chu, Ming‐Yu Wang Chu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A number of variations and derivatives of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacy‐clouridine), potent inhibitors of uridine phosphorylase were synthesized for evaluation as potential cancer chemotherapeutic agents. (“Acyclo” = 2′‐hydroxymethoxymethyl‐). These included a modification of the methylene group at N‐1, esters of the terminal hydroxyl of the acyclo group, and extension of the benzyl chain at position 5 of the uracil base. BBBAU was a very good potentiator of FUdR in cell culture.

Original languageEnglish (US)
Pages (from-to)1651-1655
Number of pages5
JournalJournal of Heterocyclic Chemistry
Volume23
Issue number6
DOIs
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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