Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

Gary B. Evans, Richard H. Furneaux, Graeme J. Gainsford, Vern L. Schramm, Peter C. Tyler

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Syntheses of the 'Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5- deoxyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)3053-3062
Number of pages10
JournalTetrahedron
Volume56
Issue number19
DOIs
StatePublished - May 5 2000

Fingerprint

Purine-Nucleoside Phosphorylase
Hydrolases
Nucleosides
5-carboxy-methylaminomethyl-2'-O-methyluridine

Keywords

  • Carbohydrate mimetics
  • Enzyme inhibitors
  • Nucleosides
  • Purines

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases. / Evans, Gary B.; Furneaux, Richard H.; Gainsford, Graeme J.; Schramm, Vern L.; Tyler, Peter C.

In: Tetrahedron, Vol. 56, No. 19, 05.05.2000, p. 3053-3062.

Research output: Contribution to journalArticle

Evans, Gary B. ; Furneaux, Richard H. ; Gainsford, Graeme J. ; Schramm, Vern L. ; Tyler, Peter C. / Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases. In: Tetrahedron. 2000 ; Vol. 56, No. 19. pp. 3053-3062.
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