Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

Gary B. Evans, Richard H. Furneaux, Graeme J. Gainsford, Vern L. Schramm, Peter C. Tyler

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Syntheses of the 'Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5- deoxyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)3053-3062
Number of pages10
JournalTetrahedron
Volume56
Issue number19
DOIs
StatePublished - May 5 2000

Keywords

  • Carbohydrate mimetics
  • Enzyme inhibitors
  • Nucleosides
  • Purines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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