Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents

Xiangshu Fei, Qi Huang Zheng, Xuan Liu, Ji Quan Wang, Hui Bin Sun, Bruce H. Mock, K. Lee Stone, Kathy D. Miller, George W. Sledge, Gary D. Hutchins

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2′,3′,4′-methoxybiphenyl-4-sulfonylamino)- butyric acid [11C]methyl ester (1a-c), (S)-3-methyl-2-(2′,3′,4′-fluorobiphenyl-4-sulfonylamino)- butyric acid [11C]methyl ester (1d-f), and (S)-3-methyl-2-(4′-nitrobiphenyl-4-sulfonylamino)-butyric acid [11C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents.

Original languageEnglish (US)
Pages (from-to)2217-2222
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number13
DOIs
StatePublished - Jul 7 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Fei, X., Zheng, Q. H., Liu, X., Wang, J. Q., Sun, H. B., Mock, B. H., Stone, K. L., Miller, K. D., Sledge, G. W., & Hutchins, G. D. (2003). Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents. Bioorganic and Medicinal Chemistry Letters, 13(13), 2217-2222. https://doi.org/10.1016/S0960-894X(03)00382-2