Synthesis of novel taxol analogs and evaluation of their biological activities

Paul A. Wender; Daesung Lee; Tapan K. Lal; Susan B. Horwitz; Srinivasa Rao

doi:10.1016/S0960-894X(97)00337-5

Synthesis of novel taxol analogs and evaluation of their biological activities

Paul A. Wender, Daesung Lee, Tapan K. Lal, Susan B. Horwitz, Srinivasa Rao

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was ~ 60-fold less active and 10 was ~ 15-fold less active.

Original language	English (US)
Pages (from-to)	1941-1944
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(97)00337-5
State	Published - Jul 22 1997

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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abstract = "Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was ~ 60-fold less active and 10 was ~ 15-fold less active.",

author = "Wender, {Paul A.} and Daesung Lee and Lal, {Tapan K.} and Horwitz, {Susan B.} and Srinivasa Rao",

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AU - Wender, Paul A.

AU - Lee, Daesung

AU - Lal, Tapan K.

AU - Horwitz, Susan B.

AU - Rao, Srinivasa

PY - 1997/7/22

Y1 - 1997/7/22

N2 - Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was ~ 60-fold less active and 10 was ~ 15-fold less active.

AB - Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was ~ 60-fold less active and 10 was ~ 15-fold less active.

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JO - Bioorganic and Medicinal Chemistry Letters

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Synthesis of novel taxol analogs and evaluation of their biological activities

Abstract

ASJC Scopus subject areas

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