Synthesis of novel taxol analogs and evaluation of their biological activities

Paul A. Wender, Daesung Lee, Tapan K. Lal, Susan B. Horwitz, Srinivasa Rao

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was ~ 60-fold less active and 10 was ~ 15-fold less active.

Original languageEnglish (US)
Pages (from-to)1941-1944
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number14
DOIs
Publication statusPublished - Jul 22 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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