Synthesis of novel taxol analogs and evaluation of their biological activities

Paul A. Wender, Daesung Lee, Tapan K. Lal, Susan Band Horwitz, Srinivasa Rao

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Two new taxol analogs 6 and 10 have been prepared from baccatin III (1) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was ~ 60-fold less active and 10 was ~ 15-fold less active.

Original languageEnglish (US)
Pages (from-to)1941-1944
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number14
DOIs
StatePublished - Jul 22 1997

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Paclitaxel
Bioactivity
Cytotoxicity
Microtubules
Stabilization

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of novel taxol analogs and evaluation of their biological activities. / Wender, Paul A.; Lee, Daesung; Lal, Tapan K.; Band Horwitz, Susan; Rao, Srinivasa.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 14, 22.07.1997, p. 1941-1944.

Research output: Contribution to journalArticle

Wender, Paul A. ; Lee, Daesung ; Lal, Tapan K. ; Band Horwitz, Susan ; Rao, Srinivasa. / Synthesis of novel taxol analogs and evaluation of their biological activities. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 14. pp. 1941-1944.
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