TY - JOUR
T1 - Synthesis of fluorescent phosphatidylinositols using a novel inositol H- phosphonate
AU - Leung, Lawrence W.
AU - Vilchèze, Catherine
AU - Bittman, Robert
N1 - Funding Information:
We thank the Michigan State University Mass Spectrometry Facility for recording the mass spectra the National Science Foundation (Grant CHE-9408535) for funds for purchase ofa 400-MHz NMR spectrometer. References and Notes
PY - 1998/5/7
Y1 - 1998/5/7
N2 - Coupling of 1,2-diradyl-sn-glycerol 5 with the novel inositol H- phosphonate derivative, 6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol H-phosphonate (3), gave fluorescent analogs of phosphatidylinositol (PtdIns, 1) and PtdIns(4,5)-bisphosphate (PtdIns(4,5)P2, 2). Unlike the corresponding phosphoramidate, 3 was stable at -20 °C for several months, making it a useful intermediate for the synthesis of myo-inositol phospholipids.
AB - Coupling of 1,2-diradyl-sn-glycerol 5 with the novel inositol H- phosphonate derivative, 6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol H-phosphonate (3), gave fluorescent analogs of phosphatidylinositol (PtdIns, 1) and PtdIns(4,5)-bisphosphate (PtdIns(4,5)P2, 2). Unlike the corresponding phosphoramidate, 3 was stable at -20 °C for several months, making it a useful intermediate for the synthesis of myo-inositol phospholipids.
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U2 - 10.1016/S0040-4039(98)00418-3
DO - 10.1016/S0040-4039(98)00418-3
M3 - Article
AN - SCOPUS:0032492945
SN - 0040-4039
VL - 39
SP - 2921
EP - 2924
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 19
ER -