Synthesis of fluorescent phosphatidylinositols using a novel inositol H- phosphonate

Lawrence W. Leung, Catherine Vilchèze, Robert Bittman

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Coupling of 1,2-diradyl-sn-glycerol 5 with the novel inositol H- phosphonate derivative, 6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol H-phosphonate (3), gave fluorescent analogs of phosphatidylinositol (PtdIns, 1) and PtdIns(4,5)-bisphosphate (PtdIns(4,5)P2, 2). Unlike the corresponding phosphoramidate, 3 was stable at -20 °C for several months, making it a useful intermediate for the synthesis of myo-inositol phospholipids.

Original languageEnglish (US)
Pages (from-to)2921-2924
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number19
DOIs
StatePublished - May 7 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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