Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand

Jeong Ju Park, Ji Hyung Lee, Subhash C. Ghosh, Gabriel Bricard, Manjunatha M. Venkataswamy, Steven A. Porcelli, Sung Kee Chung

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

KRN7000 is an important ligand identified for CD1d protein of APC, and KRN7000/CD1d complex can stimulate NKT cells to release Th1 and Th2 cytokines. In an effort to understand the structure-activity relationships, we have carried out the synthesis of a complete set of the eight KRN7000 stereoisomers, and their biological activities have been examined. Crown

Original languageEnglish (US)
Pages (from-to)3906-3909
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number14
DOIs
StatePublished - Jul 15 2008

Keywords

  • KRN7000 stereoisomers
  • NKT cell
  • Phytosphingosine
  • α-GalCer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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