Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction

Gary B. Evans; Richard H. Furneaux; Peter C. Tyler; Vern L. Schramm

doi:10.1021/ol035293q

Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction

Gary B. Evans, Richard H. Furneaux, Peter C. Tyler, Vern L. Schramm

Biochemistry

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

(Matrix Presented) The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe-Immucillin-G (3) was achieved via the Mannich reaction. The Mannich chemistry of a series of deazapurines and amine hydrochlorides was also investigated.

Original language	English (US)
Pages (from-to)	3639-3640
Number of pages	2
Journal	Organic Letters
Volume	5
Issue number	20
DOIs	https://doi.org/10.1021/ol035293q
State	Published - Oct 2 2003

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol035293q

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title = "Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction",

abstract = "(Matrix Presented) The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe-Immucillin-G (3) was achieved via the Mannich reaction. The Mannich chemistry of a series of deazapurines and amine hydrochlorides was also investigated.",

author = "Evans, {Gary B.} and Furneaux, {Richard H.} and Tyler, {Peter C.} and Schramm, {Vern L.}",

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AU - Evans, Gary B.

AU - Furneaux, Richard H.

AU - Tyler, Peter C.

AU - Schramm, Vern L.

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Y1 - 2003/10/2

N2 - (Matrix Presented) The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe-Immucillin-G (3) was achieved via the Mannich reaction. The Mannich chemistry of a series of deazapurines and amine hydrochlorides was also investigated.

AB - (Matrix Presented) The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe-Immucillin-G (3) was achieved via the Mannich reaction. The Mannich chemistry of a series of deazapurines and amine hydrochlorides was also investigated.

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Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction

Abstract

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