Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction

Gary B. Evans, Richard H. Furneaux, Peter C. Tyler, Vern L. Schramm

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

(Matrix Presented) The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe-Immucillin-G (3) was achieved via the Mannich reaction. The Mannich chemistry of a series of deazapurines and amine hydrochlorides was also investigated.

Original languageEnglish (US)
Pages (from-to)3639-3640
Number of pages2
JournalOrganic Letters
Volume5
Issue number20
DOIs
StatePublished - Oct 2 2003

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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