Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction

Gary B. Evans, Richard H. Furneaux, Peter C. Tyler, Vern L. Schramm

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

(Matrix Presented) The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe-Immucillin-G (3) was achieved via the Mannich reaction. The Mannich chemistry of a series of deazapurines and amine hydrochlorides was also investigated.

Original languageEnglish (US)
Pages (from-to)3639-3640
Number of pages2
JournalOrganic Letters
Volume5
Issue number20
DOIs
StatePublished - Oct 2 2003

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Purine-Nucleoside Phosphorylase
purines
nucleosides
hydrochlorides
inhibitors
Amines
amines
chemistry
analogs
synthesis
matrices
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)immucillin G

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction. / Evans, Gary B.; Furneaux, Richard H.; Tyler, Peter C.; Schramm, Vern L.

In: Organic Letters, Vol. 5, No. 20, 02.10.2003, p. 3639-3640.

Research output: Contribution to journalArticle

Evans, Gary B. ; Furneaux, Richard H. ; Tyler, Peter C. ; Schramm, Vern L. / Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction. In: Organic Letters. 2003 ; Vol. 5, No. 20. pp. 3639-3640.
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