TY - JOUR
T1 - Synthesis and NMR characterization of the trypanosomatid metabolite, N 1,N8-bis(glutathionyl)spermidine disulphide (trypanothione disulphide)
AU - Henderson, Graeme B.
AU - Glushka, John
AU - Cowburn, David
AU - Cerami, Anthony
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - An optimized chemical synthesis of the novel trypanosomatid metabolite, N1,N8-bis(glutathionyl)-spermidine(trypanothione disulphide) is described, and its solution structure has been investigated by NMR spectroscopy. The 1H, 13C, and 15N chemical shifts, as well as proton NOE data are compatible with two similar extended peptide segments connected by a flexible spermidine chain. The data do not support a predominant β sheet structure but indicate considerable flexibility in aqueous solution.
AB - An optimized chemical synthesis of the novel trypanosomatid metabolite, N1,N8-bis(glutathionyl)-spermidine(trypanothione disulphide) is described, and its solution structure has been investigated by NMR spectroscopy. The 1H, 13C, and 15N chemical shifts, as well as proton NOE data are compatible with two similar extended peptide segments connected by a flexible spermidine chain. The data do not support a predominant β sheet structure but indicate considerable flexibility in aqueous solution.
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U2 - 10.1039/p19900000911
DO - 10.1039/p19900000911
M3 - Article
AN - SCOPUS:37049075358
SN - 1472-7781
SP - 911
EP - 914
JO - Journal of the Chemical Society, Perkin Transactions 1
JF - Journal of the Chemical Society, Perkin Transactions 1
IS - 4
ER -