Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

Yipeng Wang, Marta Martinez-Vicente, Ulrike Krüger, Susmita Kaushik, Esther Wong, Eva Maria Mandelkow, Ana Maria Cuervo, Eckhard Mandelkow

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Tau aggregation characterizes a series of neurodegenerative diseases including AD and other tauopathies. The distribution of Tau deposits correlates with the loss of neurons in these neurodegenerative diseases, and Tauinduced toxicity depends on its ability to aggregate. We have used an inducible cell model to study the expression of Tau variants, the buildup of aggregates, and their removal by the autophagy-lysosomal system. Incomplete chaperone-mediated autophagy of Tau generates amyloidogenic fragments that promote aggregation. The Tau aggregates are removed from cells by macroautophagy. Thus the two autophagic pathways could become possible therapeutic targets.

Original languageEnglish (US)
Pages (from-to)182-183
Number of pages2
JournalAutophagy
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Aggregation
  • Alzheimer
  • Autophagy
  • Lysosome
  • Tau protein

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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