Desferrioxamine, a safe and effective iron chelator, was evaluated for its antibacterial and antifungal activity. The susceptibilities of 124 urinary tract isolates and 28 clinical isolates of Neisseria gonorrhoeae to desferrioxamine concentrations that are readily achievable in urine were determined. Of all isolates, 27% were inhibited by a concentration of ≤12.5 mM. Proteus mirabilis and N. gonorrhoeae isolates were particularly susceptible to the chelator. Desferrioxamine appears to have limited potential as an antibacterial agent.
|Original language||English (US)|
|Number of pages||2|
|Journal||Antimicrobial agents and chemotherapy|
|State||Published - 1984|
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases