Surgical Resection Provides an Overall Survival Benefit for Patients with Small Pancreatic Neuroendocrine Tumors

Susan M. Sharpe, Haejin In, David J. Winchester, Mark S. Talamonti, Marshall S. Baker

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: The optimal management of small (≤2 cm) pancreatic neuroendocrine tumors (PNETs) remains controversial. We evaluated these tumors in the National Cancer Data Base (NCDB) to determine if resection provides a survival advantage over observation.

Methods: The NCDB was queried to identify patients with nonmetastatic PNETs ≤2 cm treated between 1998 and 2006. Kaplan-Meier survival estimates, stratified by grade and treatment type, evaluated the difference in 5-year overall survival (OS) between patients who underwent resection and observation. Multivariable Cox regression was used to determine the importance of resection in OS.

Results: Three hundred eighty patients met inclusion criteria. Eighty-one percent underwent resection; 19 % were observed. Five-year OS was 82.2 % for patients who underwent surgery and 34.3 % for those who were observed (p < 0.0001). When controlling for age, comorbidities, income, facility type, tumor size and location, grade, margin status, nodal status, surgical management, and nonsurgical therapy in the Cox model, observation [hazard ratio (HR) 2.80], poorly differentiated histology (HR 3.79), lymph node positivity (HR 2.01), and nonsurgical therapies (HR 2.23) were independently associated with an increase in risk of mortality (p < 0.01).

Conclusion: Patients with localized PNETs ≤2 cm had an overall survival advantage with resection compared to observation, independent of age, comorbidities, tumor grade, and treatment with nonsurgical therapies.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume19
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Neuroendocrine Tumors
Survival
Observation
Neoplasms
Comorbidity
Databases
Therapeutics
Kaplan-Meier Estimate
Proportional Hazards Models
Histology
Lymph Nodes
Mortality

Keywords

  • Neuroendocrine
  • Pancreas
  • Surgery
  • Survival
  • Tumor

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Surgical Resection Provides an Overall Survival Benefit for Patients with Small Pancreatic Neuroendocrine Tumors. / Sharpe, Susan M.; In, Haejin; Winchester, David J.; Talamonti, Mark S.; Baker, Marshall S.

In: Journal of Gastrointestinal Surgery, Vol. 19, No. 1, 2014, p. 117-123.

Research output: Contribution to journalArticle

Sharpe, Susan M. ; In, Haejin ; Winchester, David J. ; Talamonti, Mark S. ; Baker, Marshall S. / Surgical Resection Provides an Overall Survival Benefit for Patients with Small Pancreatic Neuroendocrine Tumors. In: Journal of Gastrointestinal Surgery. 2014 ; Vol. 19, No. 1. pp. 117-123.
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