Suicidal behavior in patients with schizophrenia is related to COMT polymorphism

K. A. Nolan, J. Volavka, P. Czobor, A. Cseh, Herbert M. Lachman, T. Saito, J. Tiihonen, A. Putkonen, T. Hallikainen, I. Kotilainen, P. Räsänen, M. Isohanni, M. R. Järvelin, M. K. Karvonen

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

A common functional polymorphism that results in a three- to four-fold difference in catechol-O-methyltransferase (COMT) enzyme activity has been related to psychiatric disorders such as ultra-ultra rapid cycling bipolar disorder, drug abuse and alcoholism (Lachman et al., 1996a; Karayiorgou et al., 1997; Vandenbergh et al., 1997; Papolos et al., 1998; Tiihonen et al., 1999). Several studies have also reported associations between the allele encoding the low enzyme activity COMT variant (L allele) and other-directed aggression (Strous et al., 1997; Lachman et al., 1998; Kotler et al., 1999) in schizophrenic and schizoaffective patients. The current study investigated whether the COMT L allele is also associated with suicide attempts in schizophrenic and schizoaffective patients. COMT genotypes were determined and history of suicide attempts was retrospectively investigated in a Finnish sample (n = 94) and a US sample (n = 54). Significant associations were observed between COMT genotype and suicide; specifically, history of violent suicide attempts. The COMT L allele was more frequent in subjects who had attempted suicide by violent means. These associations were significant in males but not females. These findings support a common neurobiological substrate for self- and other-directed aggression, and suggest that catecholaminergic alterations may contribute to these behaviors in schizophrenic and schizoaffective patients.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalPsychiatric Genetics
Volume10
Issue number3
StatePublished - 2000
Externally publishedYes

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Catechol O-Methyltransferase
Schizophrenia
Suicide
Alleles
Aggression
Genotype
Attempted Suicide
Enzymes
Bipolar Disorder
Alcoholism
Substance-Related Disorders
Psychiatry

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

Nolan, K. A., Volavka, J., Czobor, P., Cseh, A., Lachman, H. M., Saito, T., ... Karvonen, M. K. (2000). Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatric Genetics, 10(3), 117-124.

Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. / Nolan, K. A.; Volavka, J.; Czobor, P.; Cseh, A.; Lachman, Herbert M.; Saito, T.; Tiihonen, J.; Putkonen, A.; Hallikainen, T.; Kotilainen, I.; Räsänen, P.; Isohanni, M.; Järvelin, M. R.; Karvonen, M. K.

In: Psychiatric Genetics, Vol. 10, No. 3, 2000, p. 117-124.

Research output: Contribution to journalArticle

Nolan, KA, Volavka, J, Czobor, P, Cseh, A, Lachman, HM, Saito, T, Tiihonen, J, Putkonen, A, Hallikainen, T, Kotilainen, I, Räsänen, P, Isohanni, M, Järvelin, MR & Karvonen, MK 2000, 'Suicidal behavior in patients with schizophrenia is related to COMT polymorphism', Psychiatric Genetics, vol. 10, no. 3, pp. 117-124.
Nolan KA, Volavka J, Czobor P, Cseh A, Lachman HM, Saito T et al. Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatric Genetics. 2000;10(3):117-124.
Nolan, K. A. ; Volavka, J. ; Czobor, P. ; Cseh, A. ; Lachman, Herbert M. ; Saito, T. ; Tiihonen, J. ; Putkonen, A. ; Hallikainen, T. ; Kotilainen, I. ; Räsänen, P. ; Isohanni, M. ; Järvelin, M. R. ; Karvonen, M. K. / Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. In: Psychiatric Genetics. 2000 ; Vol. 10, No. 3. pp. 117-124.
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AU - Czobor, P.

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AU - Lachman, Herbert M.

AU - Saito, T.

AU - Tiihonen, J.

AU - Putkonen, A.

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