Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin

Arye Rubinstein, David J. Wolf, Richard D. Granstein

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Necrobiotic xanthogranuloma (NXG) is a rare chronic disorder characterized by firm yellow to red-orange nodules and plaques affecting the face, abdomen, and extremities with the potential for systemic involvement. NXG has a close association with monoclonal gammopathies, and there is a predilection for the development of multiple myeloma. Treatment options are varied due to inconsistent results seen with the use of corticosteroids, immunomodulators, chemotherapeutic agents, and antibiotics. Objective: We describe a patient with smoldering multiple myeloma associated with progressive NXG successfully treated with high-dose intravenous immunoglobulin (IVIG). Conclusion: Our case adds to the single previous report of two cases of NXG with significant improvement from treatment with IVIG and confirms the efficacy of this treatment modality.

Original languageEnglish (US)
Pages (from-to)347-350
Number of pages4
JournalJournal of Cutaneous Medicine and Surgery
Volume17
Issue number5
DOIs
StatePublished - Sep 2013

Fingerprint

Necrobiotic Xanthogranuloma
Intravenous Immunoglobulins
Multiple Myeloma
Paraproteinemias
Immunologic Factors
Therapeutics
Abdomen
Adrenal Cortex Hormones
Extremities
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Dermatology
  • Surgery
  • Medicine(all)

Cite this

Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin. / Rubinstein, Arye; Wolf, David J.; Granstein, Richard D.

In: Journal of Cutaneous Medicine and Surgery, Vol. 17, No. 5, 09.2013, p. 347-350.

Research output: Contribution to journalArticle

@article{33b00b354b9446cd8e2002de809b1062,
title = "Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin",
abstract = "Background: Necrobiotic xanthogranuloma (NXG) is a rare chronic disorder characterized by firm yellow to red-orange nodules and plaques affecting the face, abdomen, and extremities with the potential for systemic involvement. NXG has a close association with monoclonal gammopathies, and there is a predilection for the development of multiple myeloma. Treatment options are varied due to inconsistent results seen with the use of corticosteroids, immunomodulators, chemotherapeutic agents, and antibiotics. Objective: We describe a patient with smoldering multiple myeloma associated with progressive NXG successfully treated with high-dose intravenous immunoglobulin (IVIG). Conclusion: Our case adds to the single previous report of two cases of NXG with significant improvement from treatment with IVIG and confirms the efficacy of this treatment modality.",
author = "Arye Rubinstein and Wolf, {David J.} and Granstein, {Richard D.}",
year = "2013",
month = "9",
doi = "10.2310/7750.2013.13012",
language = "English (US)",
volume = "17",
pages = "347--350",
journal = "Journal of Cutaneous Medicine and Surgery",
issn = "1203-4754",
publisher = "Decker Publishing",
number = "5",

}

TY - JOUR

T1 - Successful treatment of necrobiotic xanthogranuloma with intravenous immunoglobulin

AU - Rubinstein, Arye

AU - Wolf, David J.

AU - Granstein, Richard D.

PY - 2013/9

Y1 - 2013/9

N2 - Background: Necrobiotic xanthogranuloma (NXG) is a rare chronic disorder characterized by firm yellow to red-orange nodules and plaques affecting the face, abdomen, and extremities with the potential for systemic involvement. NXG has a close association with monoclonal gammopathies, and there is a predilection for the development of multiple myeloma. Treatment options are varied due to inconsistent results seen with the use of corticosteroids, immunomodulators, chemotherapeutic agents, and antibiotics. Objective: We describe a patient with smoldering multiple myeloma associated with progressive NXG successfully treated with high-dose intravenous immunoglobulin (IVIG). Conclusion: Our case adds to the single previous report of two cases of NXG with significant improvement from treatment with IVIG and confirms the efficacy of this treatment modality.

AB - Background: Necrobiotic xanthogranuloma (NXG) is a rare chronic disorder characterized by firm yellow to red-orange nodules and plaques affecting the face, abdomen, and extremities with the potential for systemic involvement. NXG has a close association with monoclonal gammopathies, and there is a predilection for the development of multiple myeloma. Treatment options are varied due to inconsistent results seen with the use of corticosteroids, immunomodulators, chemotherapeutic agents, and antibiotics. Objective: We describe a patient with smoldering multiple myeloma associated with progressive NXG successfully treated with high-dose intravenous immunoglobulin (IVIG). Conclusion: Our case adds to the single previous report of two cases of NXG with significant improvement from treatment with IVIG and confirms the efficacy of this treatment modality.

UR - http://www.scopus.com/inward/record.url?scp=84885810208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885810208&partnerID=8YFLogxK

U2 - 10.2310/7750.2013.13012

DO - 10.2310/7750.2013.13012

M3 - Article

C2 - 24067856

AN - SCOPUS:84885810208

VL - 17

SP - 347

EP - 350

JO - Journal of Cutaneous Medicine and Surgery

JF - Journal of Cutaneous Medicine and Surgery

SN - 1203-4754

IS - 5

ER -