Successful transplantation of a donor kidney with diffuse proliferative lupus nephritis and crescents - A case report

Sandeep Magoon, Eric Zhou, James Pullman, Stuart M. Greenstein, Daniel G. Glicklich

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Pre-existing diffuse proliferative glomerulonephritis (DPGN) in a potential deceased kidney donor has been considered a contraindication for transplantation. We report a case of a patient who underwent a successful deceased donor renal transplantation from a donor with history of systemic lupus erythematosus (SLE) whose baseline biopsy revealed DPGN. Although the histology was relatively benign in the procurement kidney biopsy done by frozen section, the final light microscopy available after transplantation showed diffuse proliferative lupus nephritis, WHO class IV, with 44% crescents. The post-transplant course was complicated by delayed allograft function requiring haemodialysis for the first week. A repeat biopsy performed after 4 months of transplant showed resolution of the proliferative lesions in the glomeruli with disappearance of the crescents. At 5.5 years of follow-up, the patient's creatinine has been stable at 2.0 mg/dL (176.8 μmol/L), but he has persistent proteinuria.

Original languageEnglish (US)
Pages (from-to)4109-4113
Number of pages5
JournalNephrology Dialysis Transplantation
Volume25
Issue number12
DOIs
StatePublished - Dec 1 2010

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Keywords

  • diffuse proliferative lupus nephritis
  • kidney transplant

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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