Substrate Ablation of Ventricular Tachycardia: Late Potentials, Scar Dechanneling, Local Abnormal Ventricular Activities, Core Isolation, and Homogenization

David F. Briceño, Jorge E. Romero, Carola Gianni, Sanghamitra Mohanty, Pedro A. Villablanca, Andrea Natale, Luigi Di Biase

Research output: Contribution to journalReview article

8 Scopus citations


Ventricular arrhythmias are a frequent cause of mortality in patients with ischemic cardiomyopathy and nonischemic cardiomyopathy. Scar-related reentry represents the most common arrhythmia substrate in patients with recurrent episodes of sustained ventricular tachycardia (VT). Initial mapping of scar-related VT circuits is focused on identifying arrhythmogenic tissue. The substrate-based strategies include targeting late potentials, scar dechanneling, local abnormal ventricular activities, core isolation, and homogenization of the scar. Even though substrate-based strategies for VT ablation have shown promising outcomes for patients with structural heart disease related to ischemic cardiomyopathy, the data are scarce for patients with nonischemic substrates.

Original languageEnglish (US)
Pages (from-to)81-91
Number of pages11
JournalCardiac Electrophysiology Clinics
Issue number1
StatePublished - Mar 1 2017



  • Structural heart disease
  • Substrate ablation
  • Ventricular arrhythmia
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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