Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury

Kris M. Mahadeo; Girish Dhall; Ashok Panigrahy; Carlos Lastra; Lawrence J. Ettinger

doi:10.3109/08880010903341904

Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury

Kris M. Mahadeo, Girish Dhall, Ashok Panigrahy, Carlos Lastra, Lawrence J. Ettinger

Pediatrics

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.

Original language	English (US)
Pages (from-to)	46-52
Number of pages	7
Journal	Pediatric Hematology and Oncology
Volume	27
Issue number	1
DOIs	https://doi.org/10.3109/08880010903341904
State	Published - Feb 8 2010

Keywords

ALL
Homocysteine
Leukemia
Methotrexate
Neurotoxicity of therapy
Thrombosis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.3109/08880010903341904

Fingerprint Dive into the research topics of 'Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury'. Together they form a unique fingerprint.

Cite this

Mahadeo, K. M., Dhall, G., Panigrahy, A., Lastra, C., & Ettinger, L. J. (2010). Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatric Hematology and Oncology, 27(1), 46-52. https://doi.org/10.3109/08880010903341904

Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism : Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. / Mahadeo, Kris M.; Dhall, Girish; Panigrahy, Ashok; Lastra, Carlos; Ettinger, Lawrence J.

In: Pediatric Hematology and Oncology, Vol. 27, No. 1, 08.02.2010, p. 46-52.

Research output: Contribution to journal › Article › peer-review

Mahadeo, KM, Dhall, G, Panigrahy, A, Lastra, C & Ettinger, LJ 2010, 'Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury', Pediatric Hematology and Oncology, vol. 27, no. 1, pp. 46-52. https://doi.org/10.3109/08880010903341904

Mahadeo KM, Dhall G, Panigrahy A, Lastra C, Ettinger LJ. Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatric Hematology and Oncology. 2010 Feb 8;27(1):46-52. https://doi.org/10.3109/08880010903341904

Mahadeo, Kris M. ; Dhall, Girish ; Panigrahy, Ashok ; Lastra, Carlos ; Ettinger, Lawrence J. / Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism : Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. In: Pediatric Hematology and Oncology. 2010 ; Vol. 27, No. 1. pp. 46-52.

@article{9dccdb6c1f104b9e8325872b070fa030,

title = "Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury",

abstract = "From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.",

keywords = "ALL, Homocysteine, Leukemia, Methotrexate, Neurotoxicity of therapy, Thrombosis",

author = "Mahadeo, {Kris M.} and Girish Dhall and Ashok Panigrahy and Carlos Lastra and Ettinger, {Lawrence J.}",

year = "2010",

month = feb,

day = "8",

doi = "10.3109/08880010903341904",

language = "English (US)",

volume = "27",

pages = "46--52",

journal = "Pediatric Hematology and Oncology",

issn = "0888-0018",

publisher = "Informa Healthcare",

number = "1",

}

TY - JOUR

T1 - Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism

T2 - Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury

AU - Mahadeo, Kris M.

AU - Dhall, Girish

AU - Panigrahy, Ashok

AU - Lastra, Carlos

AU - Ettinger, Lawrence J.

PY - 2010/2/8

Y1 - 2010/2/8

N2 - From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.

AB - From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.

KW - ALL

KW - Homocysteine

KW - Leukemia

KW - Methotrexate

KW - Neurotoxicity of therapy

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=76649098342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76649098342&partnerID=8YFLogxK

U2 - 10.3109/08880010903341904

DO - 10.3109/08880010903341904

M3 - Article

C2 - 20121554

AN - SCOPUS:76649098342

VL - 27

SP - 46

EP - 52

JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

SN - 0888-0018

IS - 1

ER -