Abstract
From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 46-52 |
| Number of pages | 7 |
| Journal | Pediatric Hematology and Oncology |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 8 2010 |
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Keywords
- ALL
- Homocysteine
- Leukemia
- Methotrexate
- Neurotoxicity of therapy
- Thrombosis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology
Cite this
Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism : Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. / Mahadeo, Kris M.; Dhall, Girish; Panigrahy, Ashok; Lastra, Carlos; Ettinger, Lawrence J.
In: Pediatric Hematology and Oncology, Vol. 27, No. 1, 08.02.2010, p. 46-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism
T2 - Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury
AU - Mahadeo, Kris M.
AU - Dhall, Girish
AU - Panigrahy, Ashok
AU - Lastra, Carlos
AU - Ettinger, Lawrence J.
PY - 2010/2/8
Y1 - 2010/2/8
N2 - From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.
AB - From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.
KW - ALL
KW - Homocysteine
KW - Leukemia
KW - Methotrexate
KW - Neurotoxicity of therapy
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=76649098342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76649098342&partnerID=8YFLogxK
U2 - 10.3109/08880010903341904
DO - 10.3109/08880010903341904
M3 - Article
C2 - 20121554
AN - SCOPUS:76649098342
VL - 27
SP - 46
EP - 52
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
SN - 0888-0018
IS - 1
ER -