Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury

Kris M. Mahadeo; Girish Dhall; Ashok Panigrahy; Carlos Lastra; Lawrence J. Ettinger

doi:10.3109/08880010903341904

Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury

Kris M. Mahadeo, Girish Dhall, Ashok Panigrahy, Carlos Lastra, Lawrence J. Ettinger

Pediatrics

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.

Original language	English (US)
Pages (from-to)	46-52
Number of pages	7
Journal	Pediatric Hematology and Oncology
Volume	27
Issue number	1
DOIs	https://doi.org/10.3109/08880010903341904
State	Published - Feb 8 2010

Keywords

ALL
Homocysteine
Leukemia
Methotrexate
Neurotoxicity of therapy
Thrombosis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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Mahadeo, K. M., Dhall, G., Panigrahy, A., Lastra, C., & Ettinger, L. J. (2010). Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatric Hematology and Oncology, 27(1), 46-52. https://doi.org/10.3109/08880010903341904

Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism : Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. / Mahadeo, Kris M.; Dhall, Girish; Panigrahy, Ashok; Lastra, Carlos; Ettinger, Lawrence J.

In: Pediatric Hematology and Oncology, Vol. 27, No. 1, 08.02.2010, p. 46-52.

Research output: Contribution to journal › Article › peer-review

Mahadeo, KM, Dhall, G, Panigrahy, A, Lastra, C & Ettinger, LJ 2010, 'Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury', Pediatric Hematology and Oncology, vol. 27, no. 1, pp. 46-52. https://doi.org/10.3109/08880010903341904

Mahadeo KM, Dhall G, Panigrahy A, Lastra C, Ettinger LJ. Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatric Hematology and Oncology. 2010 Feb 8;27(1):46-52. https://doi.org/10.3109/08880010903341904

Mahadeo, Kris M. ; Dhall, Girish ; Panigrahy, Ashok ; Lastra, Carlos ; Ettinger, Lawrence J. / Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism : Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. In: Pediatric Hematology and Oncology. 2010 ; Vol. 27, No. 1. pp. 46-52.

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Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury

Abstract

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ASJC Scopus subject areas

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