Abstract
From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 46-52 |
| Number of pages | 7 |
| Journal | Pediatric Hematology and Oncology |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 8 2010 |
Keywords
- ALL
- Homocysteine
- Leukemia
- Methotrexate
- Neurotoxicity of therapy
- Thrombosis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology
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Cite this
Mahadeo, K. M., Dhall, G., Panigrahy, A., Lastra, C., & Ettinger, L. J. (2010). Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. Pediatric Hematology and Oncology, 27(1), 46-52. https://doi.org/10.3109/08880010903341904