Abstract
From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed.
Original language | English (US) |
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Pages (from-to) | 46-52 |
Number of pages | 7 |
Journal | Pediatric Hematology and Oncology |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - Feb 8 2010 |
Keywords
- ALL
- Homocysteine
- Leukemia
- Methotrexate
- Neurotoxicity of therapy
- Thrombosis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology