Studying task-related activity of individual neurons in the human brain

Shaun R. Patel, Sameer A. Sheth, Clarissa Martinez-Rubio, Matthew K. Mian, Wael F. Asaad, Jason L. Gerrard, Churl Su Kwon, Darin D. Dougherty, Alice W. Flaherty, Benjamin D. Greenberg, John T. Gale, Ziv M. Williams, Emad N. Eskandar

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Single-neuronal studies remain the gold standard for studying brain function. Here we describe a protocol for studying task-related single-neuronal activity in human subjects during neurosurgical procedures involving microelectrode recordings. This protocol has two phases: a preoperative phase and an intraoperative phase. During the preoperative phase, we discuss informed consent, equipment setup and behavioral testing. During the intraoperative phase, we discuss the procedure for microelectrode recordings. Because patients are often awake during these procedures, this protocol can be performed in conjunction with behavioral tasks for studying a variety of cognitive functions. We describe the protocol in detail and provide two examples of expected results. In addition, we discuss the potential difficulties and pitfalls related to intraoperative studies. This protocol takes ∼1.5 h to complete.

Original languageEnglish (US)
Pages (from-to)949-957
Number of pages9
JournalNature Protocols
Volume8
Issue number5
DOIs
StatePublished - Apr 1 2013
Externally publishedYes

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Microelectrodes
Neurons
Brain
Neurosurgical Procedures
Informed Consent
Human Activities
Cognition
Equipment and Supplies
Testing
caN protocol

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Patel, S. R., Sheth, S. A., Martinez-Rubio, C., Mian, M. K., Asaad, W. F., Gerrard, J. L., ... Eskandar, E. N. (2013). Studying task-related activity of individual neurons in the human brain. Nature Protocols, 8(5), 949-957. https://doi.org/10.1038/nprot.2013.050

Studying task-related activity of individual neurons in the human brain. / Patel, Shaun R.; Sheth, Sameer A.; Martinez-Rubio, Clarissa; Mian, Matthew K.; Asaad, Wael F.; Gerrard, Jason L.; Kwon, Churl Su; Dougherty, Darin D.; Flaherty, Alice W.; Greenberg, Benjamin D.; Gale, John T.; Williams, Ziv M.; Eskandar, Emad N.

In: Nature Protocols, Vol. 8, No. 5, 01.04.2013, p. 949-957.

Research output: Contribution to journalReview article

Patel, SR, Sheth, SA, Martinez-Rubio, C, Mian, MK, Asaad, WF, Gerrard, JL, Kwon, CS, Dougherty, DD, Flaherty, AW, Greenberg, BD, Gale, JT, Williams, ZM & Eskandar, EN 2013, 'Studying task-related activity of individual neurons in the human brain', Nature Protocols, vol. 8, no. 5, pp. 949-957. https://doi.org/10.1038/nprot.2013.050
Patel SR, Sheth SA, Martinez-Rubio C, Mian MK, Asaad WF, Gerrard JL et al. Studying task-related activity of individual neurons in the human brain. Nature Protocols. 2013 Apr 1;8(5):949-957. https://doi.org/10.1038/nprot.2013.050
Patel, Shaun R. ; Sheth, Sameer A. ; Martinez-Rubio, Clarissa ; Mian, Matthew K. ; Asaad, Wael F. ; Gerrard, Jason L. ; Kwon, Churl Su ; Dougherty, Darin D. ; Flaherty, Alice W. ; Greenberg, Benjamin D. ; Gale, John T. ; Williams, Ziv M. ; Eskandar, Emad N. / Studying task-related activity of individual neurons in the human brain. In: Nature Protocols. 2013 ; Vol. 8, No. 5. pp. 949-957.
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