Structures and mechanisms of the mycothiol biosynthetic enzymes

Fan Fan, Matthew W. Vetting, Patrick A. Frantom, John S. Blanchard

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

In the past decade, the genes encoding all four enzymes responsible for the biosynthesis of mycothiol in Mycobacterium tuberculosis have been identified. Orthologs of each of these have been stably expressed and structurally characterized. The chemical mechanisms of all the four have also been studied. Because of the unique phylogenetic distribution of mycothiol, and the enzymes responsible for its biosynthesis, these enzymes represent interesting potential targets for antimycobacterial agents.

Original languageEnglish (US)
Pages (from-to)451-459
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume13
Issue number4
DOIs
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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