Structure and function of mammalian cilia

Peter Satir, Søren T. Christensen

Research output: Contribution to journalReview article

123 Scopus citations

Abstract

In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways, sometimes coupling the signaling to ciliary motility or alternatively to cell division and differentiation. This view has had unanticipated consequences for our understanding of developmental processes and human disease.

Original languageEnglish (US)
Pages (from-to)687-693
Number of pages7
JournalHistochemistry and Cell Biology
Volume129
Issue number6
DOIs
StatePublished - Jun 2008

Keywords

  • Ciliopathies
  • Motile cilia
  • Motility
  • Primary cilia
  • Sensory organelles
  • Signaling

ASJC Scopus subject areas

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology

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