Structural mechanisms of costimulation

Jean Claude D Schwartz, Xuewu Zhang, Stanley G. Nathenson, Steven C. Almo

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Recent studies have highlighted the structural requirements for T cell costimulation and have revealed unusual modes of dimerization for the cytolytic T lymphocyte-associated antigen 4 (CTLA-4) costimulatory receptor and its B7 ligands. These distinctive quaternary structures potentially endow both receptor and ligand with bivalent binding properties, which suggests a number of mechanistic features relevant to signaling. These include the potential to form a highly ordered, alternating network of CTLA-4 and B7 homodimers that may represent the organization of these molecules and their associated signaling partners within the immunological synapse. Primary sequence and structural considerations suggest that some aspects of the organizational and mechanistic features associated with the CTLA-4-B7 complexes may extend to other members of the costimulatory receptor-ligand family. An examination of the signaling mechanisms within the costimulatory receptor-ligand family provides an excellent framework to consider the general principles that are relevant to cell surface receptor-mediated signaling events.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalNature Immunology
Volume3
Issue number5
DOIs
StatePublished - 2002

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B7 Antigens
Ligands
T-Lymphocytes
Immunological Synapses
Cell Surface Receptors
Dimerization
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Schwartz, J. C. D., Zhang, X., Nathenson, S. G., & Almo, S. C. (2002). Structural mechanisms of costimulation. Nature Immunology, 3(5), 427-434. https://doi.org/10.1038/ni0502-427

Structural mechanisms of costimulation. / Schwartz, Jean Claude D; Zhang, Xuewu; Nathenson, Stanley G.; Almo, Steven C.

In: Nature Immunology, Vol. 3, No. 5, 2002, p. 427-434.

Research output: Contribution to journalArticle

Schwartz, JCD, Zhang, X, Nathenson, SG & Almo, SC 2002, 'Structural mechanisms of costimulation', Nature Immunology, vol. 3, no. 5, pp. 427-434. https://doi.org/10.1038/ni0502-427
Schwartz, Jean Claude D ; Zhang, Xuewu ; Nathenson, Stanley G. ; Almo, Steven C. / Structural mechanisms of costimulation. In: Nature Immunology. 2002 ; Vol. 3, No. 5. pp. 427-434.
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