TY - JOUR
T1 - Structural genomics of proteins from conserved biochemical pathways and processes
AU - Burley, Stephen K.
AU - Bonanno, Jeffrey B.
PY - 2002/6/1
Y1 - 2002/6/1
N2 - During the past year, X-ray crystallographers and solution NMR spectroscopists have made significant progress towards the complete structural characterization of conserved biochemical pathways and processes. Some of these advances were made in the context of nascent structural genomics programs, which promise to accelerate structural studies of biologically and medically important proteins. The results of high-throughput protein production, crystallization, structure determination, homology modeling and functional annotation published by two such programs have provided insight into the evolution and function of enzymes in the isoprenoid biosynthesis and ribulose monophosphate pathways.
AB - During the past year, X-ray crystallographers and solution NMR spectroscopists have made significant progress towards the complete structural characterization of conserved biochemical pathways and processes. Some of these advances were made in the context of nascent structural genomics programs, which promise to accelerate structural studies of biologically and medically important proteins. The results of high-throughput protein production, crystallization, structure determination, homology modeling and functional annotation published by two such programs have provided insight into the evolution and function of enzymes in the isoprenoid biosynthesis and ribulose monophosphate pathways.
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U2 - 10.1016/S0959-440X(02)00330-5
DO - 10.1016/S0959-440X(02)00330-5
M3 - Review article
C2 - 12127459
AN - SCOPUS:0036600569
SN - 0959-440X
VL - 12
SP - 383
EP - 391
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 3
ER -