Structural genomics of proteins from conserved biochemical pathways and processes

Stephen K. Burley, Jeffrey B. Bonanno

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

During the past year, X-ray crystallographers and solution NMR spectroscopists have made significant progress towards the complete structural characterization of conserved biochemical pathways and processes. Some of these advances were made in the context of nascent structural genomics programs, which promise to accelerate structural studies of biologically and medically important proteins. The results of high-throughput protein production, crystallization, structure determination, homology modeling and functional annotation published by two such programs have provided insight into the evolution and function of enzymes in the isoprenoid biosynthesis and ribulose monophosphate pathways.

Original languageEnglish (US)
Pages (from-to)383-391
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume12
Issue number3
DOIs
StatePublished - Jun 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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